Table 2 Univariate survival analysis of 331 high-risk GIST patients

Age

 ≤ 60

1

1

 60

1.25(0.88–1.53)

0.147

1.19(0.84–1.71)

0.212

Sex

 Male

1

1

 Female

1.05(0.79–1.19)

0.412

0.93(0.56–1.27)

0.670

BMI (kg/m²)

 22.78

1

1

 ≤ 22.78

0.96(0.67–1.37)

0.198

1.17(0.91–1.43)

0.219

Tumor size(cm)

 ≤ 10

1

1

 10

4.04(2.67–6.79)

 < 0.001

3.74(2.42–5.43)

0.003

Tumor site

 Stomach

1

1

 DU + SM

1.71(1.45–2.43)

0.009

1.48(1.16–1.89)

0.017

 Others

2.49(1.35–4.34)

 < 0.001

1.77(1.59–2.18)

 < 0.001

Histological variant

 Spindle

1

1

 Epithelioid

0.87(0.74–1.40)

0.122

0.69(0.54–1.27)

0.208

 Mixed

1.08(1.01–1.33)

0.028

0.97(0.95–1.09)

0.091

Surgery

 Local excision

1

1

 Contained DTE

1.26(0.89–1.73)

0.011

1.11(1.09–1.24)

0.032

 Extensive radical surgery

1.86(0.91–2.42)

 < 0.001

2.47(1.71–3.39)

 < 0.001

Ki-67 index(%)

 ≤ 10

1

1

 10

3.14(2.40–4.67)

 < 0.001

2.43(1.96–3.51)

 < 0.001

Mitotic rate

 ≤ 10/50

1

1

 10/50

2.79(2.16–4.08)

 < 0.001

2.13(1.76–3.09)

 < 0.001

TKI therapy

 Regular

1

1

 Irregular + no drug

3.11(2.08–4.55)

 < 0.001

2.47(1.84–3.91)

 < 0.001