Table 2 Univariable and multivariable Cox regression analysis of factors associated with overall survival in ypT1-2N0 patients

Age (years)

1.017 (0.991–1.043)

0.193

–

Gender

–

 Female

1 (ref.)

 Male

1.033 (0.533–2.004)

0.923

BMI

1.057 (0.952–1.175)

0.297

–

Tumor size (cm)

1.191 (0.909–1.560)

0.204

 cT2

1 (ref.)

1 (ref.)

 cT3

3.073 (0.991–9.532)

0.052

2.875 (0.998–8.281)

0.050

 cT4

5.685 (1.405–23.002)

0.015

7.382 (2.569–21.211)

< 0.001

 cN−

1 (ref.)

1 (ref.)

 cN+

1.974 (1.010–3.860)

0.047

1.099 (0.430–2.807)

0.343

No. of NACT cycles

–

 2

1 (ref.)

 3

1.266 (0.456–3.516)

0.651

 4

0.574 (0.212–1.559)

0.276

Tumor location

–

 Upper third

1 (ref.)

 Middle third

1.211 (0.560–2.619)

0.627

 Lower third

0.641 (0.277–1.484)

0.299

Type of resection

–

 Subtotal

1 (ref.)

 Total

1.264 (0.658–2.429)

0.482

Lauren type

–

 Intestinal

1 (ref.)

 Diffuse/mixed

1.405 (0.725–2.726)

0.314

 Well/moderate

1 (ref.)

1 (ref.)

 Poor

1.883 (0.978–3.623)

0.058

1.399 (0.537–3.645)

0.492

Signet ring cell

–

 No

1 (ref.)

 Yes

1.674 (0.867–3.231)

0.125

Pathological T stage

–

 ypT1

1 (ref.)

 ypT2

1.237 (0.619–2.474)

0.547

No. of lymph nodes

1.031 (0.947–1.122)

0.487

–

 No

1 (ref.)

1 (ref.)

 Yes

1.770 (0.920–3.403)

0.052

1.029 (0.408–2.598)

0.251

Pathological response

–

 CAP 0

1 (ref.)

 CAP 1

1.701 (0.512–5.651)

0.386

 CAP 2

1.550 (0.494–4.870)

0.453

 CAP 3

2.352 (0.767–7.219)

0.135

 No

1 (ref.)

 Yes

0.910 (0.473–1.750)

0.777