Fig. 5

Regulatory mechanism of BRIP1 and the correlated genes expression and its role in cancer. a The correlation between DNA methylation and the expression levels of BRIP1 and the correlated genes in different cancers. b SNV frequency of BRIP1 and the correlated genes in different cancers. The deeper of color, the higher of mutate frequency. c Global profile that shows the constitute of heterozygous/homozygous CNV of BRIP1 and the correlated genes in each cancer. Hete Amp, heterozygous amplification; Hete Del, heterozygous deletion. Homo Amp, homozygous amplification; Homo Del, homozygous deletion; None, no CNV. d The association between paired mRNA expression and CNV percent samples, based on Pearson’s product moment correlation coefficient