Fig. 3

BRIP1-related gene enrichment analysis. a We first obtained the available experimentally determined BRIP1-binding proteins using the STRING database. b Using the GEPIA2 tool, we also obtained the top 100 BRIP1-correlated genes in TCGA projects and analyzed the expression correlation between BRIP1 and the top five genes with the highest correlation, including CLSPN, PLOD3, CALU, GCC1, and MYBBP1A. c The corresponding heatmap data in the detailed cancer types are displayed. d An intersection analysis of the BRIP1-binding and correlated genes was conducted. e, f KEGG and GO enrichment analyses predicted the functional roles of target genes based on four aspects, including KEGG pathway analysis, biological process, cellular components, and molecular functions. The count represents the number of genes in a GO/KEGG term