Table 3 Univariate Cox regression analysis for prognosis and relative hazard of death in GBC patients

Age

26–45

1

-

Reference

46–65

1.471

1.029–2.102

0.034*

Gender

Female

1

-

Reference

Male

1.018

0.726–1.427

0.917

Region

Rural

1

-

Reference

Urban

1.590

1.050–2.408

0.028*

Dietary habit

Vegetarian

1

-

Reference

Nonvegetarian

1.224

0.822–1.824

0.320

Tobacco chewing

Non-chewer

1

-

Reference

Chewer

1.402

0.769–1.412

0.792

Jaundice

Absent

1

-

Reference

Present

1.574

1.150–2.155

0.005*

Gallstones

Absent

1

-

Reference

Present

2.778

1.902–4.057

< 0.0001**

Liver infiltration

Absent

1

-

Reference

Present

1.832

1.239–2.710

0.002*

Any chronic disease

Absent

1

-

Reference

Present

1.113

0.756–1.640

0.587

Histology

Adenocarcinoma

1

-

Reference

Non-adenocarcinoma

1.778

1.083–2.917

0.023*

Grade

I/II

1

-

Reference

III/IV

1.604

1.171–2.199

0.003*

Tumor location

Fundus

1

-

Reference

Body-neck

1.183

0.867–1.615

0.289

Clinical stage

I/II

1

-

Reference

III/IV

1.712

1.148–2.555

0.008*

T stage

T1/T2

1

-

Reference

T3/T4

2.583

1.772–3.765

< 0.0001**

N stage

N0

1

-

Reference

N1/N2

1.750

1.280–2.392

< 0.0001**

M stage

M0

1

-

Reference

M1

3.870

2.649–5.652

< 0.0001**

Surgery

No

1

-

Reference

Yes

0.280

0.179–0.438

< 0.0001**

Radiation

No

1

-

Reference

Yes

0.278

0.155–0.499

< 0.0001**

Chemotherapy

No

1

-

Reference

Yes

0.912

0.599–1.388

0.667