Table 4 Univariate and multivariate analysis of risks factors for early recurrence

Age > 65 year

1.02 (0.41–2.53)

0.963

-

-

-

-

DM^b

2.03 (0.78–4.80)

0.153

2.82 (7.51–1.06)

0.038

3.05 (1.15-8.13)

0.025

HBV^c

1.21 (0.75–1.94))

0.431

-

-

-

-

HCV^d

1.04 (0.62–1.61)

0.986

-

-

-

-

Liver cirrhosis

2.09 (0.84–5.17)

0.111

1.56 (0.58–4.16)

0.375

-

-

ICG-15^e > 10%

3.31 (1.39–7.87)

0.007

4.28 (1.62–11.30)

0.003

4.48 (1.74-11.49)

0.002

AFP^f > 200 ng/mL

2.28 (0.92–5.67)

0.074

1.83 (0.67–4.98)

0.231

-

-

Significant muscle loss

3.45 (1.33–8.91)

0.010

3.13 (1.08–9.02)

0.034

3.22 (1.17-8.84)

0.023

Pre-op sarcopenia

1.23 (0.49–3.04)

0.654

-

-

-

-

Laparoscopic procedure

0.59 (0.24–1.43)

0.246

-

-

-

-

Tumor rupture

3.58 (0.83–15.43)

0.086

1.16 (0.09–1.42)

0.905

-

-

Resection margin < 0.5 cm

1.42 (0.60–3.34)

0.421

-

-

-

-

Vessel invasion

1.82 (0.73–4.52)

0.194

-

-

-

-

AJCC^g cancer stage ≧ III

3.85 (1.13–13.11)

0.031

6.29 (0.71–55.21)

0.097

7.41 (1.81-30.30)

0.005

Major postoperative complication^h

1.18 (0.15–8.85)

0.867

-

-

-

-