Table 1 Basic characteristics of the included studies
Study | Year | Region | Con source | Number | Ages (cases/con) | Genotyping method | Cases | Con | HWE | NOS score | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases/con | II | DI | DD | II | DI | DD | ||||||||
Sierra [18] | 2009 | Mexico | PB | 19/28 | NR | PCR-RFLP | 0 | 7 | 12 | 9 | 12 | 7 | 0.464 | 8 |
van der Knaap [17] | 2008 | Netherlands | PB | 209/6015 | 70.4±9.7/70.4±9.7 | PCR | 44 | 109 | 56 | 1332 | 3006 | 1677 | 0.828 | 8 |
Wang [19] | 2012 | China | HB | 189/290 | 71.58±7.69/72.51±8.10 | PCR | 49 | 84 | 56 | 115 | 135 | 40 | 0.970 | 7 |
Yigit [16] | 2007 | Turkey | PB | 48/51 | 70.55±9.68/69.02±7.89 | PCR-RFLP | 4 | 19 | 25 | 12 | 24 | 15 | 0.692 | 8 |
Hasanzad [20] | 2013 | Iran | HB | 84/96 | 67±8.7/67±8.7 | PCR-RFLP | 18 | 27 | 39 | 16 | 32 | 48 | 0.014 | 8 |
Said [12] | 2021 | Tunisia | PB and HB | 124/143 | 70.78 ± 9.258 /69.67 ± 9.03 | PCR | 10 | 50 | 64 | 27 | 58 | 58 | 0.075 | 8 |
Shubbar a [10] | 2018 | Iraq | PB | 75/81 | 68.03±5.73/56.42±3.95 | PCR | 10 | 20 | 45 | 36 | 18 | 27 | 0.000 | 8 |
Shubbar b [10] | 2018 | Iraq | HB | 75/75 | 68.03±5.73/49.28±6.10 | PCR | 10 | 20 | 45 | 20 | 35 | 20 | 0.564 | 8 |
Asmahan a [11] | 2020 | Lebanon | PB | 69/69 | 66.4±8.5/55.8±11.0 | PCR | 7 | 43 | 19 | 8 | 34 | 27 | 0.582 | 8 |
Asmahan b [11] | 2020 | Lebanon | HB | 69/69 | 66.4±8.5/69.1±8.4 | PCR | 7 | 43 | 19 | 1 | 48 | 20 | 0.000 | 8 |