High co-expression of immune checkpoint receptors PD-1, CTLA-4, LAG-3, TIM-3, and TIGIT on tumor-infiltrating lymphocytes in early-stage breast cancer

Table 2 Significant correlations of immune checkpoint receptors (ICR) on TILs and PBLs

		PBL PD-1⁺ CD8⁺	PBL TIM-3⁺ CD8⁺	PBL TIGIT⁺ CD16⁺	PBL TIM-3⁺ CD16⁺	PBL CTLA-4⁺ CD56⁺
TIL PD-1⁺CD8⁺	R	− 0.98	0.05	− 0.75	0.55	− 0.72
TIL PD-1⁺CD8⁺	p	0.0001	0.91	0.08	0.25	0.10
TIL TIM-3⁺CD8⁺	R	− 0.46	0.75	− 0.31	0.81	− 0.11
TIL TIM-3⁺CD8⁺	p	0.35	0.08	0.53	0.05	0.82
TIL TIGIT⁺CD16⁺	R	− 0.75	0.26	− 0.84	0.46	− 0.72
TIL TIGIT⁺CD16⁺	p	0.08	0.61	0.03	0.35	0.10
TIL TIM-3⁺CD16⁺	R	− 0.37	0.63	− 0.25	0.77	− 0.25
TIL TIM-3⁺CD16⁺	p	0.46	0.17	0.62	0.07	0.62
TIL CTLA-4⁺CD56⁺	R	− 0.81	− 0.27	− 0.84	0.11	− 0.81
TIL CTLA-4⁺CD56⁺	p	0.05	0.59	0.03	0.82	0.05

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