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Table 1 Demographic, pathological features and surgical interventions

From: High co-expression of immune checkpoint receptors PD-1, CTLA-4, LAG-3, TIM-3, and TIGIT on tumor-infiltrating lymphocytes in early-stage breast cancer

 

n

%

Age (year)

Median (min–max)

49 (26–68)

Mean ± SD

50.27 ± 10.83

≤ 50

18

56.3

> 50

14

43.7

Menopausal status

Premenopausal

17

53.2

Postmenopausal

15

46.8

Surgical interventions

Simple mastectomy

5

15.6

Areola sparing mastectomy

12

37.5

Skin sparing mastectomy

1

3.1

Breast conserving surgery

14

43.8

Axillary approach

SLNB (−)

24

75

SLNB (+)

5

15.7

ALND

3

9.3

HER-2

Negative

21

65.7

Positive

11

34.3

ER

Negative

7

21.8

Positive

25

78.2

PR

Negative

12

37.5

Positive

20

62.5

Ki-67 (%)

Median (Min–Max)

32.5 (12–90)

Mean ± SD

38.9 ± 18.8

Ki-67 ≤ 20

5

15.6

Ki-67 > 20

27

84.4

Histological grade

Grade 2

10

31.2

Grade 3

22

68.8

High TIL density (>10%)

Negative

20

62.5

Positive

12

37.5

Receptor status

Luminal B

26

81.2

HER2 positive

3

9.4

Triple negative

3

9.4

Luminal

Negative

6

18.7

Positive

26

81.3

T stage

T1

9

28.1

T2

23

71.9

N stage

N0

23

71.9

N1

9

28.1

Stage

Stage 1

9

28.1

Stage 2

23

71.9

Lymphovascular invasion

Negative

16

50

Positive

16

50

Extensive intraductal component

Negative (< 20%)

21

65.7

Positive (> 20%)

11

34.3