Fig. 8
Overview of the CapG-involved motility pathway. It is derived from the present study outcomes that CapG is involved in Rho motility pathway independent of ROCK and inactivates Rac1. It is reasonably deduced that CapG-mediated Ca2+ signaling and Ca2+-dependent MLCK contribute to MLC phosphorylation. Arrows indicate activation. Truncated arrows mean inhibition. ROCK, rho-associated protein kinase; p-MLC, phosphorylated-myosin light chain; MLCK, myosin light chain kinase