Literature review of imaging, pathological diagnosis, and outcomes of metachronous lung and pancreatic metastasis of cecal cancer

Table 1 Targeted next-generation sequencing of 520 cancer-related genes from the primary sigmoid cancer, lung metastasis, and pancreatic resection

Mutated gene and impact on protein sequence	Cecal tumor	Lung tumor	Pancreatic tumor
KRAS p.G12D	+	+	+
APC p.K1310Rfs*11	+	+	+
APC p.H1490Ifs*17	+	+	+
TP53 c.560-1G>A	+	+	+
TP53 p.T81Nfs*68	+	+	+
TP53 p.R273H	+	+	+
FBXW7 p.E573*	+	+	+
FBXW7 p.G663R	+	+	+
PTEN p.T319fs	+	+	+
PIK3CA p.E545K	+	+	+
PIK3CA p.E542K	+
ERCC1 p·N118N	+
ERCC5 p.T106M	+
CDKMN2A p.R80*			+
LRP1B p.A3643D	+
LRP1B p.P1191T		+
XRCC1 p·Q399R	+
TSHR p.D487N			+
ASXL1 p.G668S			+
FGF3 p.A87S		+
EZH2 p.D731fs		+

+ positive, KRAS KRAS proto-oncogene, GTPase; APC APC regulator of WNT signaling pathway, TP53 tumor protein p53, FBXW7 F-box and WD repeat domain containing 7, PTEN phosphatase and tensin homolog, ERCC1 excision repair cross-complementing group 1, ERCC5 excision repair cross-complementing rodent repair deficiency, complementation group 5, CDKMN2A cyclin-dependent kinase inhibitor 2A, LRP1B LDL receptor-related protein 1B, PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1, TSHR thyroid-stimulating hormone receptor, FGF3 fibroblast growth factor 3

ISSN: 1477-7819