Table 1 Details of studies included in the meta-analysis
First author/year | Country | Population Selection | Variables matched | Total Sample | AR | NAR | NOS Score |
|---|---|---|---|---|---|---|---|
Cho 2019 [14] | Korea | Small solitary HCC with MVI (< 5Â cm) | Age; sex; albumin; AST; ALT; tumor size; vascular invasion; operating time; blood loss | 118 | 59 | 59 | 8 |
Cucchetti 2014 [7] | Italy-China | Child A; early HCC; surgical margin ≥ 1 cm; Single nodule < 5 cm or up to 3 nodules < 3cm | Age; HCV; HbsAg; albumin; MELD score; solitary tumors; size; G3-G4; MVI | 298 | 149 | 149 | 7 |
Haruki 2021 [8] | Japan | Small solitary HCC (< 5cm) | Age; sex; HBV; HCV; ICG-R15; Child-Pugh grade; tumor size; AFP; tumor number | 132 | 66 | 66 | 8 |
Hokuto 2018 [9] | Japan | Extended to a depth of < 3 cm from the liver surface and measured < 5cm in diameter | Age; Gender; HBsAg; HCV-Ab; AFP; DCP; AST; ALT; albumin; operation time; tumor size; microvascular invasion | 40 | 20 | 20 | 8 |
Ishii 2014 [10] | Japan | HCC patients undergoing hepatectomy | Age; gender; albumin; bilirubin; PT; size; Tumor number; Operation time; blood loss | 88 | 44 | 44 | 7 |
Kaibori 2017 [11] | Japan | Curative resection; Solitary tumor ≤ 5cm; ICG-R15 ≤ 15%; | Age; HCV; HBV; bilirubin; ALT; albumin; PLT; ICG-R15; AFP; blood loss; operative time; size; MVI | 710 | 355 | 355 | 8 |
Kwon 2022 [13] | Korea | Curative resection; Solitary tumor ≤ 5cm | Age; sex; HBV; HCV; Child-Pugh grade; PLT; total bilirubin; ICG-R15 | 341 | 224 | 117 | 7 |
Minagawa 2022 [12] | Japan | Solitary HCC (≤ 5cm) | Age; sex; HBV; HCV; total bilirubin; AST; ALT | 134 | 67 | 67 | 8 |