Fig. 3

Construction of the IRGscore. a IRGscore differences among three immune clusters (P < 0.001, Student’s t-test). b Differences in IRGscore across three gene clusters (P < 0.001, Student’s t-test). c Correlations between IRGscore and immune infiltrating cells of TME analyzed by Spearman’s analysis. Red and blue colors represent positive and negative correlations, respectively. d The expression of genes related to immune checkpoints in low and high IRGscore groups. e The expression of immune activation-related genes in high and low IRGscore groups. f GSVA analysis (c2.cp.kegg.v7.4.symbols.gmt) revealed that the signaling pathways related to immune activation were remarkably enriched in low IRGscore samples. g The alluvial diagram indicated the attribute alterations in different patterns