Skip to main content

Table 2 Alleles and genotypes distribution and the risk of APOE polymorphism in different groups

From: Effects of APOE gene ε4 allele on serum lipid profiles and risk of cardiovascular disease and tumorigenesis in southern Chinese population

  Control (N = 322) Tumor (N = 409) Unadjusted
OR (95% CI)
CVD (N = 369) Unadjusted
OR (95% CI)
CVD + tumor (N = 338) Unadjusted
OR (95% CI)
Allele
  ε2 25 (3.9%) 38 (4.6%) 1.21 (0.72–2.02) 45 (6.1%) 1.61 (0.97–2.65) 28 (4.1%) 1.07 (0.62–1.86)
  ε3 595 (92.4%) 716 (87.5%) 0.58 (0.4–0.83)** 605 (82%) 0.38 (0.27–0.53)*** 591 (87.4%) 0.57 (0.4–0.83)**
  ε4 24 (3.7%) 64 (7.8%) 2.19 (1.36–3.55)*** 88 (11.9%) 3.5 (2.2–5.57)*** 57 (8.4%) 2.38 (1.46–3.88)***
Total 644 818   738   676  
Genotype
  E2/E2 1 (0.3%) 1 (0.2%) 0.79 (0.05–12.63) 2 (0.5%) 1.75 (0.16–19.38) 2 (0.6%) 1.91 (0.17–21.18)
  E2/E3 20 (6.2%) 29 (7.1%) 1.15 (0.64–2.08) 35 (9.5%) 1.58 (0.89–2.8) 22 (6.5%) 1.05 (0.56–1.97)
  E2/E4 3 (0.9%) 7 (1.7%) 1.85 (0.48–7.22) 6 (1.6%) 1.76 (0.44–7.09) 2 (0.6%) 0.63 (0.11–3.81)
  E3/E3 278 (86.3%) 317 (77.5%) 0.55 (0.37–0.81)** 246 (66.7%) 0.32 (0.22–0.47)*** 258 (76.3%) 0.51 (0.34–0.77)***
  E3/E4 19 (5.9%) 53 (13%) 2.37 (1.38–4.1)*** 78 (21.1%) 4.28 (2.53–7.24)*** 53 (15.7%) 2.97 (1.71–5.13)***
  E4/E4 1 (0.3%) 2 (0.5%) 1.59 (0.14–17.47) 2 (0.5%) 1.75 (0.16–19.38) 1 (0.3%) 0.95 (0.06–15.29)
Total 322 409   369   338  
HDW P = 0.15 P = 0.18   P = 0.56   P = 0.31  
  1. Data are presented as numbers (percentage), HDW Hardy-Weinberg equilibrium, *P < 0.05: comparison with control, CI confidence interval