Table 2 Alleles and genotypes distribution and the risk of APOE polymorphism in different groups

Allele

  ε2

25 (3.9%)

38 (4.6%)

1.21 (0.72–2.02)

45 (6.1%)

1.61 (0.97–2.65)

28 (4.1%)

1.07 (0.62–1.86)

  ε3

595 (92.4%)

716 (87.5%)

0.58 (0.4–0.83)**

605 (82%)

0.38 (0.27–0.53)***

591 (87.4%)

0.57 (0.4–0.83)**

  ε4

24 (3.7%)

64 (7.8%)

2.19 (1.36–3.55)***

88 (11.9%)

3.5 (2.2–5.57)***

57 (8.4%)

2.38 (1.46–3.88)***

Total

644

818

738

676

Genotype

  E2/E2

1 (0.3%)

1 (0.2%)

0.79 (0.05–12.63)

2 (0.5%)

1.75 (0.16–19.38)

2 (0.6%)

1.91 (0.17–21.18)

  E2/E3

20 (6.2%)

29 (7.1%)

1.15 (0.64–2.08)

35 (9.5%)

1.58 (0.89–2.8)

22 (6.5%)

1.05 (0.56–1.97)

  E2/E4

3 (0.9%)

7 (1.7%)

1.85 (0.48–7.22)

6 (1.6%)

1.76 (0.44–7.09)

2 (0.6%)

0.63 (0.11–3.81)

  E3/E3

278 (86.3%)

317 (77.5%)

0.55 (0.37–0.81)**

246 (66.7%)

0.32 (0.22–0.47)***

258 (76.3%)

0.51 (0.34–0.77)***

  E3/E4

19 (5.9%)

53 (13%)

2.37 (1.38–4.1)***

78 (21.1%)

4.28 (2.53–7.24)***

53 (15.7%)

2.97 (1.71–5.13)***

  E4/E4

1 (0.3%)

2 (0.5%)

1.59 (0.14–17.47)

2 (0.5%)

1.75 (0.16–19.38)

1 (0.3%)

0.95 (0.06–15.29)

Total

322

409

369

338

HDW

P = 0.15

P = 0.18

P = 0.56

P = 0.31