Fig. 2

A Microscopic picture (H&E stain) revealed Paget’s disease with associated extensive DCIS (H&E, × 100 original magnification). B Paget’s disease characterized by infiltration of the epidermis by large tumor cells showing pale vacuolated cytoplasm and pleomorphic nuclei (H&E, × 100 original magnification). (CD) Negative estrogen receptor (ER) and progesterone receptor (PR) immunostaining in the Paget cells (× 100 original magnification). (EF) Her-2-positive cells and cytokeratin-7 (CK7)-positive cells constituting Paget’s disease (immunohistochemistry, × 100 original magnification)