Prognostic and clinicopathologic significance of circZFR in multiple human cancers

Table 4 The ceRNA regulation of circZFR in various cancers

Cancer type	miRNA	mRNA	Function
BlC	miR-516a-5p	FBXL18	Growth, metastasis, chemo-resistance [24]
BlC	miR-377	ZEB2	Cell growth, migration, invasion, cell cycle, apoptosis [18]
BrC	miR-578	HIF1A	Proliferation, apoptosis, migration, invasion, ATP levels [19]
	miR-532-3p	–	Proliferation, migration, invasion, EMT [20]^a
	–	PI3K/AKT	Proliferation, apoptosis [36]
CRC	miR-532-3p	FOXO4	Proliferation, migration [37]
ESCC	miR-377	VEGF	Proliferation, migration, invasion [23]
GC	miR-101-3p	–	Migration, invasion [21]
GC	miR-130a，miR-107	PTEN	Proliferation, cell cycle, apoptosis [38]^a
HCC	miR-1270	PLAGL2	Proliferation, migration, invasion, EMT [39]
	–	MAP2K1	Proliferation, stemness [15]
	miR-620	–	Proliferation, migration, invasion [40]^a
	miR-3619-5p	CTNNB1, Wnt/β-catenin pathway	Proliferation, EMT [28]
	miR-375	HMGA2	Proliferation, glycolytic metabolism, apoptosis [29]
	miR-511	AKT1	Proliferation, migration, invasion, apoptosis [30]
	miR-377-3p	FGFR1	Proliferation, cycle progression, migration [31]
LC	miR-4302	ZNF121-dependent MYC expression	Proliferation, invasion [16]
	miR-377-3p	GOT1	Cisplatin-resistance, proliferation, viability, apoptosi s[41]
	miR-377-5p	NOVA2	Proliferation, motility [32]
	miR-545-3p	CBLL1	Growth, apoptosis, cell cycle, migration, invasion [42]
	miR-195-5p	KPNA4	Paclitaxel resistance, cell cycle, apoptosis [14]
	miR-101-3p	CUL4B	Proliferation, migration, invasion [33]
PTC	miR-1261	C8orf4	Proliferation, migration, invasion [17]
RCC	miR-206	Met-Wnt/β-catenin and PI3K/AKT	Growth, migration, invasion [43]

Abbreviations: BlC bladder cancer, BrC breast cancer, CRC colorectal cancer, ESCC esophageal squamous cell cancer, GC gastric cancer, HCC hepatocellular carcinoma, LC lung cancer, PTC papillary thyroid cancer, RCC renal cell carcinoma
^acircZFR acts as tumor suppressor genes

ISSN: 1477-7819