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Table 4 The ceRNA regulation of circZFR in various cancers

From: Prognostic and clinicopathologic significance of circZFR in multiple human cancers

Cancer type miRNA mRNA Function
BlC miR-516a-5p FBXL18 Growth, metastasis, chemo-resistance [24]
miR-377 ZEB2 Cell growth, migration, invasion, cell cycle, apoptosis [18]
BrC miR-578 HIF1A Proliferation, apoptosis, migration, invasion, ATP levels [19]
miR-532-3p Proliferation, migration, invasion, EMT [20]a
PI3K/AKT Proliferation, apoptosis [36]
CRC miR-532-3p FOXO4 Proliferation, migration [37]
ESCC miR-377 VEGF Proliferation, migration, invasion [23]
GC miR-101-3p Migration, invasion [21]
miR-130a,miR-107 PTEN Proliferation, cell cycle, apoptosis [38]a
HCC miR-1270 PLAGL2 Proliferation, migration, invasion, EMT [39]
MAP2K1 Proliferation, stemness [15]
miR-620 Proliferation, migration, invasion [40]a
miR-3619-5p CTNNB1, Wnt/β-catenin pathway Proliferation, EMT [28]
miR-375 HMGA2 Proliferation, glycolytic metabolism, apoptosis [29]
miR-511 AKT1 Proliferation, migration, invasion, apoptosis [30]
miR-377-3p FGFR1 Proliferation, cycle progression, migration [31]
LC miR-4302 ZNF121-dependent MYC expression Proliferation, invasion [16]
miR-377-3p GOT1 Cisplatin-resistance, proliferation, viability, apoptosi s[41]
miR-377-5p NOVA2 Proliferation, motility [32]
miR-545-3p CBLL1 Growth, apoptosis, cell cycle, migration, invasion [42]
miR-195-5p KPNA4 Paclitaxel resistance, cell cycle, apoptosis [14]
miR-101-3p CUL4B Proliferation, migration, invasion [33]
PTC miR-1261 C8orf4 Proliferation, migration, invasion [17]
RCC miR-206 Met-Wnt/β-catenin and PI3K/AKT Growth, migration, invasion [43]
  1. Abbreviations: BlC bladder cancer, BrC breast cancer, CRC colorectal cancer, ESCC esophageal squamous cell cancer, GC gastric cancer, HCC hepatocellular carcinoma, LC lung cancer, PTC papillary thyroid cancer, RCC renal cell carcinoma
  2. acircZFR acts as tumor suppressor genes