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Table 4 The ceRNA regulation of circZFR in various cancers

From: Prognostic and clinicopathologic significance of circZFR in multiple human cancers

Cancer type

miRNA

mRNA

Function

BlC

miR-516a-5p

FBXL18

Growth, metastasis, chemo-resistance [24]

miR-377

ZEB2

Cell growth, migration, invasion, cell cycle, apoptosis [18]

BrC

miR-578

HIF1A

Proliferation, apoptosis, migration, invasion, ATP levels [19]

miR-532-3p

Proliferation, migration, invasion, EMT [20]a

PI3K/AKT

Proliferation, apoptosis [36]

CRC

miR-532-3p

FOXO4

Proliferation, migration [37]

ESCC

miR-377

VEGF

Proliferation, migration, invasion [23]

GC

miR-101-3p

Migration, invasion [21]

miR-130a,miR-107

PTEN

Proliferation, cell cycle, apoptosis [38]a

HCC

miR-1270

PLAGL2

Proliferation, migration, invasion, EMT [39]

MAP2K1

Proliferation, stemness [15]

miR-620

Proliferation, migration, invasion [40]a

miR-3619-5p

CTNNB1, Wnt/β-catenin pathway

Proliferation, EMT [28]

miR-375

HMGA2

Proliferation, glycolytic metabolism, apoptosis [29]

miR-511

AKT1

Proliferation, migration, invasion, apoptosis [30]

miR-377-3p

FGFR1

Proliferation, cycle progression, migration [31]

LC

miR-4302

ZNF121-dependent MYC expression

Proliferation, invasion [16]

miR-377-3p

GOT1

Cisplatin-resistance, proliferation, viability, apoptosi s[41]

miR-377-5p

NOVA2

Proliferation, motility [32]

miR-545-3p

CBLL1

Growth, apoptosis, cell cycle, migration, invasion [42]

miR-195-5p

KPNA4

Paclitaxel resistance, cell cycle, apoptosis [14]

miR-101-3p

CUL4B

Proliferation, migration, invasion [33]

PTC

miR-1261

C8orf4

Proliferation, migration, invasion [17]

RCC

miR-206

Met-Wnt/β-catenin and PI3K/AKT

Growth, migration, invasion [43]

  1. Abbreviations: BlC bladder cancer, BrC breast cancer, CRC colorectal cancer, ESCC esophageal squamous cell cancer, GC gastric cancer, HCC hepatocellular carcinoma, LC lung cancer, PTC papillary thyroid cancer, RCC renal cell carcinoma
  2. acircZFR acts as tumor suppressor genes