Table 4 Diagnostic indices for CA19-9, CA125, CEA and their combination
| Â | CA19-9 | CA125 | CA125 | CEA | CA19-9 and/or CA125 positive | CA19-9 and/or CA125 positive | CA19-9 and/or CEA positive | CA19-9 and/or CA125 and/or CEA positive | CA19-9 and/or CA125 and/or CEA positive |
|---|---|---|---|---|---|---|---|---|---|
Cutoff value | 38.3 U/mL | 13.4 U/mL | 35 U/mL | 5.3 ug/l | 38.3 U/mL and 13.4 U/mL | 38.3 U/mL and 35 U/mL | 38.3 U/mL and 5.3 ug/l | 38.3 U/mL and 13.4 U/mL and 5.3 ug/l | 38.3 U/mL and 35 U/mL and 5.3 ug/l |
Sensitivity | 51.1% | 45.9% | 5.9% | 25.2% | 68.9% | 52.6% | 59.3% | 73.3% | 60.0% |
Specificity | 90.7% | 73.2% | 99.6% | 94.3% | 68.7% | 90.7% | 85.8% | 65.4% | 85.8% |
Positive predictive value | 75.0% | 48.4% | 88.9% | 70.8% | 54.7% | 75.5% | 69.6% | 53.8% | 69.8% |
Negative predictive value | 77.2% | 71.1% | 65.9% | 69.6% | 80.1% | 77.7% | 79.3% | 81.7% | 79.6% |
Accuracy | 76.6% | 63.5% | 66.4% | 69.8% | 68.8% | 77.2% | 76.4% | 68.2% | 76.6% |
OR | 10.14 | 2.32 | 15.43 | 5.58 | 4.86 | 10.76 | 8.77 | 5.21 | 9.04 |