Table 1 Baseline characteristics in patients with solitary LM, 2–4 LM, ≥ 5 LM
Characteristic | N = 1 | N = 2–4 | N ≥ 5 | p value |
|---|---|---|---|---|
(n = 375) | (n = 424) | (n = 296) | ||
Gender | ||||
 Male | 243 (64.80) | 264 (62.26) | 202 (68.24) | 0.255 |
 Female | 132 (35.20) | 160 (37.74) | 94 (31.76) |  |
Age | ||||
 < 60 | 195 (52.00) | 218 (51.42) | 193 (65.20) | < 0.001 |
 ≥ 60 | 180 (48.00) | 206 (48.58) | 103 (34.80) |  |
Primary site | ||||
 Left | 304 (81.07) | 352 (83.02) | 244 (82.43) | 0.766 |
 Right | 71 (18.93) | 72 (16.98) | 52 (17.57) |  |
Primary tumor T stage | ||||
 T1−2 | 39 (10.40) | 34 (8.02) | 20 (6.76) | 0.220 |
 T3−4 | 336 (89.60) | 390 (91.98) | 276 (93.24) |  |
Primary tumor lymph node status | ||||
 Negative | 129 (34.40) | 133 (31.37) | 78 (26.35) | 0.081 |
 Positive | 246 (65.60) | 291 (68.63) | 218 (73.65) |  |
RAS mutation | 155 (41.33) | 168 (39.62) | 126 (42.57) | 0.722 |
Preoperative chemotherapy | ||||
 No | 182 (48.53) | 72 (16.98) | 14 (4.73) | < 0.001 |
 Yes | 193 (51.47) | 352 (83.02) | 282 (95.27) |  |
Disease-free interval | ||||
 ≥ 12 m | 134 (35.73) | 59 (13.92) | 11 (3.72) | < 0.001 |
< 12 m | 241 (64.27) | 365 (86.08) | 285 (96.28) | Â |
Bilobar distribution | 27 (7.2) | 260 (61.32) | 269 (90.88) | < 0.001 |
Maximum tumor diameter ≥ 5 cm | 66 (17.60) | 49 (11.56) | 22 (7.43) | < 0.001 |
Pulmonary metastases | 42 (11.20) | 50 (11.79) | 31 (10.47) | 0.859 |
Margin status | ||||
 R0 | 344 (91.73) | 363 (85.61) | 214 (72.30) | |
 R1 | 29 ( 7.73) | 56 (13.21) | 72 (24.32) | < 0.001 |
 R2 | 2 ( 0.53) | 5 ( 1.18) | 10 ( 3.38) |  |
Hepatic resection | ||||
 Minor | 338 (90.13) | 339 (79.95) | 171 (57.77) | < 0.001 |
 Major | 37 (9.87) | 85 (20.05) | 125 (42.23) |  |
Intraoperative ablation | 9 (2.40) | 76 (17.92) | 133 (44.93) | < 0.001 |
Simultaneous resection | ||||
 No | 305 (81.33) | 321 (75.71) | 229 (77.36) | 0.149 |
 Yes | 70 (18.67) | 103 (24.29) | 67 (22.64) |  |
CEA level (ng/ml) | ||||
< 200 | 366 (97.60) | 409 (96.46) | 290 (97.97) | 0.419 |
 ≥ 200 | 9 (2.40) | 15 (3.54) | 6 (2.03) |  |
CA19-9 level (IU/ml) | ||||
 < 50 | 278 (74.13) | 330 (77.83) | 224 (75.68) | 0.470 |
 ≥ 50 | 97 (25.87) | 94 (22.17) | 72 (24.32) |  |
Perioperative RBC transfusion | 19 (5.07) | 33 (7.78) | 33 (11.15) | 0.014 |