Fig. 5

HPSE was involved in multiple biological processes in ESCC tissues. A The results of GSEA (GO terms) showed that the high HPSE expression group was enriched in oxidoreductase activity acting on metal ions, peptide cross linking, and the nucleotide sugar biosynthetic process. B The enriched GO pathways in samples with low HPSE expression. C The GSEA results (KEGG pathways) showed that samples with high HPSE expression were significantly enriched in cytokine–cytokine receptor interactions, the Jak-STAT signaling pathway, and retinol metabolism. D Enriched KEGG pathways in the low HPSE expression group