Fig. 3

Analysis of DEGs with expression not affected by tumor purity and hypoxia. A Densogram representing the variance in tumor purity among tumor samples in GSE53625. B The network diagram presents correlations of gene expression and tumor purity, which were calculated using Spearman’s correlation analysis (|Spearman correlation coefficient| ≥ 0.4, p value ≤ 0.001). C The Venn diagram shows the overlapping genes among four groups of genes independent of tumor purity. D Genes correlated with hypoxia were identified in GSE53625 (|Spearman correlation coefficient| ≥ 0.4, p value ≤ 0.001). E The Venn diagram shows overlapping genes among four groups of genes independent of hypoxia. F DEGs independent of tumor purity and hypoxia in the three overlapping groups