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Table 5 Logistic regression analysis of variables associated with neutropenia

From: GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity induced by anthracycline-/paclitaxel-based chemotherapy in breast cancer patients

Variables

Unadjusted values

Adjusted values

P value

OR (95% CI)

P value

Adjusted OR (95% CI)

Age (≤ 50/ > 50)

0.163

0.515 (0.202–1.309)

0.127

0.252 (0.043–1.483)

Menopause (no/yes)

0.733

0.853 (0.341–2.131)

0.324

2.446 (0.414–14.440)

T-stage (T3-T4/T0-T2)

0.965

1.020 (0.413–2.520)

0.593

1.316 (0.481–3.597)

N-stage (N2-N3/N0-N1)

0.313

0.578 (0.199–1.678)

0.320

0.553 (0.172–1.776)

Clinical stage (IV/I–III)

0.911

1.064 (0.360–3.142)

0.860

1.113 (0.340–3.637)

Molecular subtype (TNBC/non-TNBC)

0.817

1.168 (0.313–4.367)

0.450

1.747 (0.410–7.442)

Chemotherapy regimen/dose ((docetaxel 75 mg/m2 and epirubicin 75 mg/m2)/(docetaxel 90 mg/m2 and epirubicin 90 mg/m2))

0.197

2.014 (0.695–5.835)

0.124

2.454 (0.782–7.697)

GSTP1 c.313A > G (A/G + G/G vs. A/A)

0.031

4.038 (1.132–14.395)

0.031

4.273 (1.141–16.000)

  1. TNBC Triple-negative breast cancer