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Table 2 Univariable and multivariable analyses for PHLF grade B–C in the training cohort

From: An mALBI-Child–Pugh-based nomogram for predicting post-hepatectomy liver failure grade B–C in patients with huge hepatocellular carcinoma: a multi-institutional study

Variables Univariable logistic regression Multivariable logistic regression
β P value OR 95% CI β P value OR 95% CI
Age, years  − 0.001 0.961 0.999 0.975–1.024   NA   
Male gender  − 0.035 0.937 0.966 0.406–2.296   NA   
ALT, U/L 0.006 0.055 1.006 1.000–1.011   NA   
AST, U/L 0.015 0.001 1.015 1.007–1.023   NS   
γ-GT, U/L 0.000 0.617 1.000 0.999–1.002   NS   
PT, s 0.661 0.001 1.936 1.461–2.565   NS   
INR 10x 0.914 0.001 2.493 1.733–3.506 0.529 0.005 1.698 1.198–2.501
Hilar occlusion ≥ 20 min 0.032 0.926 1.033 0.522–2.043   NA   
Intraoperative blood loss ≥ 300 ml 1.439 0.001 4.219 2.262–7.866 1.082 0.004 2.952 1.430–6.235
Major resection 1.909 0.063 6.747 0.903–50.413   NA   
Open hepatectomy 19.498 0.999 0.000 0.000–imponderable   NA   
Cirrhosis 1.665 0.002 5.287 1.850–15.109 1.392 0.019 4.022 1.397–15.037
HBsAg positive 0.279 0.418 1.322 0.673–2.597   NA   
HBeAg positive 1.024 0.005 2.785 1.370–5.662   NS   
HBV DNA positive 0.268 0.402 1.307 0.699–2.443   NA   
Multiple tumors  − 0.179 0.554 0.836 0.463–1.511   NA   
AFP, ng/mL  < 20   0.168     -   
20–400  − 0.506 0.287 0.603 0.237–1.531   NA   
 > 400 0.318 0.343 1.375 0.712–2.655   NA   
mALBI grade 1   0.001     -   
2a 1.315 0.001 3.724 1.791–7.744 1.087 0.009 2.966 1.297–6.765
2b 2.599 0.001 13.453 5.887–30.745 2.126 0.001 8.383 3.197–22.508
BCLC stage A   0.642     -   
B  − 0.286 0.477 0.751 0.341–1.654   NA   
C  − 0.282 0.413 0.754 0.384–1.482   NA   
Child–Pugh B class 2.426 0.001 11.310 3.908–32.732 1.343 0.044 3.830 1.057–14.844
  1. OR Odds ratio, CI Confidence interval, INR International normalized ratio, mALBI Modified albumin-bilirubin, AFP α-fetoprotein, ALT Alanine aminotransferase, AST Aspartate transaminase, γ-GT gamma-glutamyl transferase, PT Prothrombin time, PHLF Post-hepatectomy liver failure, NA Not adopted, NS Not significant