Table 2 Clinicopathological features of patients according to lymph node metastasis
No LNM (n = 520) | LNM (n = 294) | p-value | |
|---|---|---|---|
Gender | < 0.001 | ||
Female | 435 (83.7%) | 209 (71.1%) | |
Male | 85 (16.3%) | 85 (28.9%) | |
Age (years, mean ± SD) | 48.11 ± 11.6 | 41.7 ± 11.3 | < 0.001 |
Histologic variation | < 0.001 | ||
Conventional | 315 (60.6%) | 236 (80.3%) | |
Follicular variant | 192 (36.9%) | 53 (18.0%) | |
Tall cell variant | 3 (0.6%) | 0 (0%) | |
Other | 10 (1.9%) | 5 (1.7%) | |
Lymphatic invasion | 5 (1.0%) | 17 (5.8%) | < 0.001 |
Perineural invasion | 3 (0.6%) | 10 (3.4%) | 0.003 |
Vascular invasion | 1 (0.2%) | 4 (1.4%) | 0.060 |
ETE | < 0.001 | ||
No | 406 (78.1%) | 187 (63.6%) | |
Minimal | 108 (20.8%) | 96 (32.7%) | |
Gross | 6 (1.2%) | 11 (3.7%) | |
BRAF mutation | 105/168 (62.5%) | 66/98 (67.3%) | 0.507 |
Extent of surgery | < 0.001 | ||
Total thyroidectomy | 313 (60.2%) | 248 (84.4%) | |
Lobectomy | 201 (38.7%) | 43 (14.6%) | |
Wide isthmusectomy | 6 (1.2%) | 3 (1.0%) |