Table 3 Immunohistochemical findings

Histological type (2019 WHO classification)

 SCNEC

0

 LCNEC

7

 MiNEN

6

Lymphatic invasion

 0/1/2/3

2/6/3/2

Vascular invasion

 01/2/3

5/1/4/3

Coexistence of adenocarcinoma

 Absent

4

 Present

9

Neuroendocrine markers

 CD56

  Positive/negative

8/5

 Chromogranin A

  Positive/negative

12/1

 Synaptophysin

  Positive/negative

13/0

Differentiation

 Mitotic score

  Median; range

66 (0–400)

 Ki-67 index %

  Median; range

60 (0–95)