Fig. 1

IRLs selected by Lasso regression analysis and random forest (RF). A The two dotted vertical lines are drawn at the optimal values by minimum criteria (right) and 1-se criteria (left). B Lasso coefficient profiles of the 11 IRLs. A vertical line is drawn at the optimal value by 1-se criteria and results in 11 nonzero coefficients. C Distribution diagram of regression tree and error. D The top 15 most important variables ranked by IncNodePurity. E Venn diagram presents the intersection of three results to identify hub genes