Fig. 5

KIF14 knockdown arrests the cell cycle by inhibiting p27 degradation. HeLa cells were divided into siNC, siKIF14, p27 KD, and siKIF14+p27 KD groups. A The trends in the changes associated with KIF14 and cyclin-associated protein expression levels were reversed in the si-KIF14+p27 KD group compared with the si-KIF14 group. B Cell viability as detected via CCK-8 assays. C A clone formation assay was used to detect the proliferation ability. D Detection of cell migration ability. Scale bar = 100 μm. E. Detection of cell invasion ability. Scale bar = 100 μm. *p < 0.05, **p < 0.01, and ***p < 0.001