Parenchyma-sparing strategy and oncological prognosis in patients with colorectal cancer liver metastases

Table 1 Univariate and multivariate analysis for overall survival prognosis

	n	Univariate		Multivariate
	n	Median, months	P	B-factor	P
Preoperative factors
T_1–2	27	-	0.32	0.54	0.21
T_3–4	158	31.6	0.32
N₋	93	-	0.24	−0.34	0.44
N₊	78	30.9	0.24
M₀	82	-	0.21	0.98	0.79
M₁	103	39.2	0.21
Primary tumor site
Right colon	28	25.4	0.52	−0.83	0.13
Left colon	157	-	0.52
Lung metastases
Yes	18	16.7	0.001	−0.41	0.53
No	167	-	0.001
KRAS status				2.3	0.001
Mutation	48	14.6	0.001
Wild type	137	-	0.001
Tumor burden of the liver
Number of metastatic cites
1–5	99	39.2	0.67	−0.67	0.12
> 5	86	25.4	0.67
Size of metastatic lesion^a
< 50 mm	132	66.2	0.99	0.36	0.45
≥ 50 mm	53	35.1	0.99
Involved segments
1–3	127	-	0.001	0.96	0.02
≥ 4	58	14.6	0.001
Predominant location of metastatic lesions
Central	78	-	0.3	0.35	0.46
Peripheral	107	37.4	0.3
Surgical factors
Resection margin
R₀	158	-	0.44	−0.66	0.91
R_1v	27	28.1	0.44

“-”Median survival not reached at the time of analysis; ^ain case of multiple lesions, the largest lesion size was chosen; В Beta coefficient. In current equation, the independent variable is the overall cumulative survival rate

ISSN: 1477-7819