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Table 2 Logistic regression analysis of the risk factors for LM in CRC patients

From: Nomogram for predicting occurrence of synchronous liver metastasis in colorectal cancer: a single-center retrospective study based on pathological factors

Characteristics Univariate analysis Multivariate analysis
OR [95% CI] P value OR [95% CI] P value
Age (years)
 < 60 0.966 [0.526–1.774] 0.912   
 60–74 0.858 [0.469–1.572] 0.621   
 ≥ 75 Ref    
BMI
 < 25 1.151 [0.538–1.151] 0.538   
 ≥ 25 Ref    
Sex
 Male 1.004 [0.664–1.516] 0.987   
 Female Ref    
Tumor site
 Right-sited colon 2.787 [1.764–4.402] < 0.001 2.228 [1.272–3.901] 0.005
 Left-sited colon 1.446 [0.857–2.441] 0.168 1.635 [0.889–3.007] 0.114
 Rectum Ref   Ref  
Tumor size (cm)
 ≤ 5 0.670 [0.450–0.998] 0.049 1.033 [0.638–1.671] 0.896
 > 5 Ref   Ref  
Tumor type
 Ulcer type 0.438 [0.096–2.009] 0.288   
 Uplift type 0.226 [0.047–1.102] 0.066   
 Infiltrating type Ref    
Grade
 I/II Ref   Ref  
 III/IV 2.793 [1.779–4.384] < 0.001 0.982 [0.555–1.737] 0.949
Histology
 Adenocarcinoma 0.297 [0.083–1.055] 0.060   
 Mucinous 0.421 [0.113–1.568] 0.197   
 Others Ref    
T
 T1/T2 0.049 [0.007–0.354] 0.003 0.130 [0.017–1.014] 0.052
 T3 0.321 [0.203–0.507] < 0.001 0.417 [0.245–0.710] 0.001
 T4 Ref   Ref  
N
 N0 0.123 [0.077–0.199] < 0.001 0.246 [0.128–0.472] < 0.001
 N1 0.263 [0.156–0.443] < 0.001 0.308 [0.165–0.573] < 0.001
 N2 Ref   Ref  
LNE
 < 12 0.920 [0.531–1.595] 0.767   
 ≥ 12 Ref    
Vascular invasion
 No 0.258 [0.171–0.387] < 0.001 0.509 [0.306–0.846] 0.009
 Yes Ref   Ref  
Nerve invasion
 No 0.402 [0.253–0.637] < 0.001 1.050 [0.594–1.856] 0.866
 Yes Ref   Ref  
Lymphatic invasion
 No 0.547 [0.367–0.817] 0.003 1.383 [0.810–2.363] 0.235
 Yes Ref   Ref  
CEA
 Positive 0.148 [0.095–0.232] < 0.001 0.329 [0.198–0.545] < 0.001
 Negative Ref   Ref  
CA199
 Positive 0.080 [0.052–0.123] < 0.001 0.167 [0.103–0.270] < 0.001
 Negative Ref   Ref