Role of the triad of procalcitonin, C-reactive protein, and white blood cell count in the prediction of anastomotic leak following colorectal resections

Table 4 Predictive performance of CRP, PCT, and WBC Trajectories for the anastomotic leak

Trajectories	AUC	95% CI	SN	SP	PPV	NPV
CRP > 50 mg/l
Between any 2 days	0.84^*	0.79–0.89	90.9	77.6	32.7	98.6
From POD 1 to POD 2	0.83^*	0.76–0.88	86.4	80.3	34.5	98.0
From POD 2 to POD 3	0.85^*	0.80–0.90	81.8	88.5	46.1	97.6
From POD 3 to POD 4	0.81^*	0.75–0.86	72.7	89.6	45.6	96.5
From POD 4 to POD 5	0.78^*	0.71–0.83	59.1	96.2	64.9	95.2
PCT > 0.5 ng/ml
Between any 2 days	0.93^*	0.88–0.96	95.5	89.6	52.4	99.4
From POD 1 to POD 2	0.79^*	0.73–0.84	68.2	89.6	44.0	95.9
From POD 2 to POD 3	0.86^*	0.80–0.90	77.3	94.5	62.9	97.2
From POD 3 to POD 4	0.87^*	0.81–0.91	77.3	96.2	70.8	97.2
From POD 4 to POD 5	0.92^*	0.87–0.95	86.4	97.3	79.1	98.3
WBC > 1.0 (× 1000/mm³)
Between any 2 days	0.75^*	0.68–0.80	100	49.2	19.1	100
From POD 1 to POD 3	0.72^*	0.65–0.78	86.4	57.4	19.5	97.2
From POD 3 to POD 5	0.84^*	0.78–0.89	90.9	77.0	32.2	98.6

CRP C-reactive protein, PCT procalcitonin, WBC white blood cell count, SN sensitivity, SP specificity, PPV positive predictive value, NPV negative predictive value, POD post-operative day
^*Statistically significant different AUC from the reference diagonal line at p value < 0.05

ISSN: 1477-7819