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Table 4 Predictive performance of CRP, PCT, and WBC Trajectories for the anastomotic leak

From: Role of the triad of procalcitonin, C-reactive protein, and white blood cell count in the prediction of anastomotic leak following colorectal resections

Trajectories AUC 95% CI SN SP PPV NPV
CRP > 50 mg/l
Between any 2 days 0.84* 0.79–0.89 90.9 77.6 32.7 98.6
  From POD 1 to POD 2 0.83* 0.76–0.88 86.4 80.3 34.5 98.0
  From POD 2 to POD 3 0.85* 0.80–0.90 81.8 88.5 46.1 97.6
  From POD 3 to POD 4 0.81* 0.75–0.86 72.7 89.6 45.6 96.5
  From POD 4 to POD 5 0.78* 0.71–0.83 59.1 96.2 64.9 95.2
PCT > 0.5 ng/ml
Between any 2 days 0.93* 0.88–0.96 95.5 89.6 52.4 99.4
  From POD 1 to POD 2 0.79* 0.73–0.84 68.2 89.6 44.0 95.9
  From POD 2 to POD 3 0.86* 0.80–0.90 77.3 94.5 62.9 97.2
  From POD 3 to POD 4 0.87* 0.81–0.91 77.3 96.2 70.8 97.2
  From POD 4 to POD 5 0.92* 0.87–0.95 86.4 97.3 79.1 98.3
WBC > 1.0 (× 1000/mm3)
Between any 2 days 0.75* 0.68–0.80 100 49.2 19.1 100
  From POD 1 to POD 3 0.72* 0.65–0.78 86.4 57.4 19.5 97.2
  From POD 3 to POD 5 0.84* 0.78–0.89 90.9 77.0 32.2 98.6
  1. CRP C-reactive protein, PCT procalcitonin, WBC white blood cell count, SN sensitivity, SP specificity, PPV positive predictive value, NPV negative predictive value, POD post-operative day
  2. *Statistically significant different AUC from the reference diagonal line at p value < 0.05