Table 4 Univariate and Multivariate analysis of prognostic factors for PBTC subgroup
Factors | n(%) | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
mOS(95%CI) | χ2 | p | B | HR(95%CI) | P | ||
Age (years) | |||||||
 ≤40 | 8 (3.9) | 5.0 (0.0-25.7) | 2.455 | 0.653 | - | - | - |
 41-50 | 19 (9.2) | 8.2 (3.7-12.7) |  |  | - | - | - |
 51-60 | 66 (31.9) | 9.0 (5.4-12.6) |  |  | - | - | - |
 61-70 | 78 (37.7) | 8.2 (6.2-10.2) |  |  | - | - | - |
 ≥71 | 36 (17.4) | 8.3 (6.3-10.3) |  |  | - | - | - |
Sex | |||||||
 Male | 115 (55.6) | 7.0 (5.6-8.4) | 1.589 | 0.208 | - | - | - |
 Female | 92 (44.4) | 9.7 (8.3-11.1) |  |  | - | - | - |
Pain on the back and loin | |||||||
 No | 128 (61.8) | 8.2 (6.0-10.4) | 0.909 | 0.340 | - | - | - |
 Yes | 79 (38.2) | 8.7 (6.7-10.8) |  |  | - | - | - |
Smoking history | |||||||
 No | 139 (67.1) | 9.6 (8.0-11.2) | 1.807 | 0.179 | - | - | - |
 Yes | 68 (32.9) | 7.0 (5.7-8.3) |  |  | - | - | - |
Diabetes history | |||||||
 No | 119 (57.5) | 9.0 (7.6-10.4) | 0.864 | 0.353 | - | - | - |
 Yes | 88 (42.5) | 7.0 (5.0-9.0) |  |  | - | - | - |
CA199(U/ml) | |||||||
 <37 | 50 (24.2) | 10.5 (6.1-14.9) | 41.985 | 0.000 |  | Reference |  |
 ≥37and<200 | 54 (26.1) | 12.0 (9.4-14.6) |  |  | 0.056 | 1.058 (0.647-1.729) | 0.823 |
 ≥200and<400 | 24 (11.6) | 10.6 (8.0-13.2) |  |  | 0.175 | 1.191 (0.642-2.211) | 0.579 |
 ≥400and<800 | 28 (13.5) | 7.6 (4.0-11.2) |  |  | 0.757 | 2.131 (1.162-3.909) | 0.015 |
 ≥800 | 51 (24.6) | 5.0 (4.1-5.9) |  |  | 0.813 | 2.255 (1.305-3.897) | 0.004 |
CEA (ng/ml) | |||||||
 <5 | 127 (61.4) | 10.6 (8.8-12.4) | 17.747 | 0.000 |  | Reference |  |
 ≥5 | 80 (38.6) | 6.0 (5.4-6.7) |  |  | 0.508 | 1.661 (1.152-2.397) | 0.007 |
Albumin(g/L) | |||||||
 <35 | 15 (7.2) | 3.2 (0.0-7.8) | 1.494 | 0.222 | - | - | - |
 ≥35 | 192 (92.8) | 8.7 (7.1-10.3) |  |  | - | - | - |
Total bilirubin (umol/l) | |||||||
 <22 | 184 (88.9) | 8.8 (7.3-10.3) | 9.531 | 0.023 |  | Reference |  |
 ≥22and<100 | 21 (10.1) | 5.4 (5.0-5.8) |  |  | 0.620 | 1.858 (1.070-3.229) | 0.028 |
 ≥100and<200 | 1 (0.5) | - |  |  | -1.082 | 0.339 (0.038-3.042) | 0.334 |
 ≥200 | 1 (0.5) | - |  |  | 1.780 | 5.927 (0.752-46.746) | 0.091 |
Peripancreatic invasion | |||||||
 No | 46 (22.2) | 13.4 (6.5-20.3) | 10.891 | 0.000 |  | Reference |  |
 Yes | 161 (77.8) | 7.5 (6.1-8.9) |  |  | 0.501 | 1.650 (1.077-2.529) | 0.021 |
Degree of weight loss (kg) | |||||||
 <5 | 123 (59.4) | 9.0 (7.5-10.5) | 0.567 | 0.452 | - | - | - |
 ≥5 | 84 (40.6) | 7.0 (5.5-8.5) |  |  | - | - | - |
NLRa | |||||||
 <2 | 36 (17.4) | 9.0 (5.8-12.2) | 0.028 | 0.868 | - | - | - |
 ≥2 | 171 (82.6) | 8.3 (6.7-9.9) |  |  | - | - | - |
NLRb | |||||||
 <3 | 99 (47.8) | 9.0 (6.7-11.3) | 0.000 | 0.993 | - | - | - |
 ≥3 | 108 (52.2) | 8.2 (6.6-9.8) |  |  | - | - | - |
NLRc | |||||||
 <4 | 124 (59.9) | 9.0 (7.3-10.7) | 0.190 | 0.663 | - | - | - |
 ≥4 | 83 (40.1) | 7.5 (5.8-9.2) |  |  | - | - | - |
NLRd | |||||||
 <5 | 180 (87.0) | 9.0 (7.5-10.5) | 5.990 | 0.014 |  | Reference |  |
 ≥5 | 27 (13.0) | 3.4 (0.0-8.1) |  |  | 0.500 | 1.649 (1.009-2.696) | 0.046 |
Operative procedure | |||||||
 Without operation | 79 (38.2) | 5.8 (4.9-6.7) | 21.185 | 0.000 |  | Reference |  |
 Palliative operation | 10 (4.8) | 2.0 (0.7-3.3) |  |  | 0.615 | 1.850 (0.817-4.189) | 0.140 |
 Radical resection | 118 (57.0) | 11.0 (8.4-13.6) |  |  | 0.153 | 1.166 (0.785-1.731) | 0.447 |
Tumor size (cm) | |||||||
 d<2 | 4 (1.9) | 6.0 (0.0-14.1) | 2.697 | 0.260 | - | - | - |
 2≤d<4 | 74 (35.7) | 9.0 (6.1-11.9) |  |  | - | - | - |
 d≥4 | 129 (62.3) | 8.1 (6.6-9.6) |  |  | - | - | - |
Hepatic metastasis | |||||||
 No | 41 (19.8) | 10.0 (8.7-11.3) | 30.997 | 0.000 |  | Reference |  |
 Yes | 166 (80.2) | 4.5 (2.4-6.6) |  |  | 0.462 | 1.588 (0.966-2.610) | 0.068 |
Lymph node metastasis | |||||||
 No | 141 (68.1) | 7.1 (4.0-20.2) | 0.091 | 0.763 | - | - | - |
 Yes | 66 (31.9) | 8.7 (7.2-10.2) |  |  | - | - | - |
Number of distant organ metastasis | |||||||
 0 | 119 (57.5) | 11.0 (9.3-12.7) | 36.997 | 0.000 |  | Reference |  |
 1 | 51 (24.6) | 6.0 (4.5-7.5) |  |  | 0.468 | 1.597 (1.009-2.527) | 0.046 |
 ≥2 | 37 (17.9) | 4.0 (2.4-5.6) |  |  | 0.771 | 2.163 (1.268-3.690) | 0.005 |
Adjuvant chemotherapy | |||||||
 No | 188 (90.8) | 7.7 (6.2-9.2) | 5.857 | 0.016 |  | Reference |  |
 Yes | 19 (9.2) | 17.5 (7.7-27.3) |  |  | -1.077 | 0.340 (0.182-0.638) | 0.001 |