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Table 1 Univariate and Multivariate analysis of prognostic factors for PC

From: Prognosis and survival analysis of patients with pancreatic cancer: retrospective experience of a single institution

Factors n(%) Univariate analysis Multivariate analysis
mOS(95%CI) χ2 p B HR(95%CI) P
Age (years)
 ≤40 17 (2.7) 7.4 (4.1-10.7) 13.178 0.010   Reference  
 41-50 72 (11.5) 12.0 (9.9-14.1)    -0.154 0.857 (0.461-1.594) 0.626
 51-60 215 (34.4) 8.7 (7.5-9.9)    0.128 1.136 (0.638-2.024) 0.664
 61-70 224 (35.8) 10.3 (8.8-11.8)    0.125 1.133 (0.637-2.016) 0.671
 ≥71 97 (15.5) 7.3 (5.4-9.2)    0.273 1.314 (0.719-2.401) 0.375
Sex
 Male 341 (54.6) 8.6 (7.5-9.7) 2.412 0.120 - - -
 Female 284 (45.4) 10.5 (9.2-11.8)    - - -
Pain on the back and loin
 No 463 (74.1) 9.5 (8.4-10.6) 0.094 0.759 - - -
 Yes 162 (25.9) 9.1 (7.4-10.8)    - - -
Smoking history
 No 396 (63.4) 9.8 (8.8-10.8) 1.243 0.265 - - -
 Yes 229 (36.6) 8.5 (7.1-9.9)    - - -
Diabetes history
 No 352 (43.7) 9.0 (8.0-10.0) 0.446 0.504 - - -
 Yes 273 (56.3) 9.6 (8.1-11.1)    - - -
CA199(U/ml)
 <37 129 (20.6) 14.5 (10.9-18.1) 67.567 0.000   Reference  
 ≥37and<200 159 (25.4) 11.0 (9.1-12.9)    0.282 1.326 (0.984-1.788) 0.064
 ≥200and<400 89 (14.2) 10.7 (8.7-12.7)    0.399 1.490 (1.057-2.099) 0.023
 ≥400and<800 101 (16.2) 9.0 (7.9-10.1)    0.474 1.606 (1.157-2.229) 0.005
 ≥800 147 (23.5) 5.7 (5.0-6.4)    0.767 2.153 (1.558-2.975) 0.000
CEA (ng/ml)
 <5 400 (64.0) 11.0 (9.9-12.1) 22.771 0.000   Reference  
 ≥5 225 (36.0) 6.7 (6.0-7.4)    0.187 1.205 (0.983-1.478) 0.073
Albumin(g/L)
 <35 76 (12.2) 6.7 (4.5-8.9) 5.128 0.024   Reference  
 ≥35 549 (87.8) 9.7 (8.8-10.6)    -0.137 0.872 (0.643-1.183) 0.379
Total bilirubin (umol/l)
 <22 342 (54.7) 9.0 (8.0-10.0) 8.922 0.030   Reference  
 ≥22and<100 74 (11.8) 7.0 (4.4-9.6)    0.262 1.300 (0.950-1.799) 0.102
 ≥100and<200 97 (15.5) 10.7 (8.2-13.2)    -0.060 0.942 (0.702-1.264) 0.689
 ≥200 112 (17.9) 11.3 (8.9-13.7)    0.031 1.032 (0.767-1.388) 0.836
Peripancreatic invasion
 No 242 (38.7) 13.8 (11.3-16.3) 32.275 0.000   Reference  
 Yes 383 (61.3) 7.4 (6.5-8.3)    0.207 1.230 (0.995-1.519) 0.055
Degree of weight loss (kg)
 <5 358 (57.3) 10.7 (9.6-11.8) 7.755 0.000   Reference  
 ≥5 267 (42.7) 7.8 (6.8-8.8)    0.162 1.176 (0.969-1.427) 0.102
NLRa
 <2 135 (21.6) 8.7 (6.9-10.5) 1.765 0.184 - - -
 ≥2 490 (87.4) 9.6 (8.6-10.6)    - - -
NLRb
 <3 307 (49.1) 9.6 (8.2-11.0) 0.050 0.823 - - -
 ≥3 318 (50.9) 9.1 (7.8-10.4)    - - -
NLRc
 <4 375 (60.0) 9.7 (8.6-10.8) 1.264 0.261 - - -
 ≥4 250 (40.0) 9.0 (8.0-10.0)    - - -
NLRd
 <5 545 (87.2) 10.0 (9.1-10.9) 8.602 0.003   Reference  
 ≥5 80 (12.8) 7.4 (5.5-9.3)    0.296 1.344 (1.021-1.769) 0.035
Operative procedure
 Without operation 179 (28.6) 6.0 (5.3-6.7) 65.658 0.000   Reference  
 Palliative operation 81 (13.0) 6.0 (5.2-6.8)    -0.050 0.951 (0.688-1.316) 0.762
 Radical resection 365 (58.4) 12.3 (10.3-14.3)    -0.310 0.734 (0.573-0.940) 0.014
Tumor location
 Head 413 (66.1) 9.9 (8.7-11.2) 4.484 0.106 - - -
 Body/tail 207 (33.1) 8.4 (6.7-10.1)    - - -
 All 5 (0.8) 11.0 (8.9-13.1)    - - -
Tumor size (cm)
 d<2 36 (5.8) 12.0 (2.3-21.7) 9.756 0.000   Reference  
 2≤d<4 314 (50.2) 10.4 (9.2-11.6)    -0.229 0.796 (0.527-1.201) 0.277
 d≥4 275 (44.0) 8.2 (7.0-9.4)    -0.035 0.966 (0.630-1.480) 0.873
Hepatic metastasis
 No 540 (86.4) 10.7 (9.7-11.7) 82.708 0.000   Reference  
 Yes 85 (13.6) 4.5 (3.3-5.7)    0.190 1.209 (0.850-1.720) 0.290
Lymph node metastasis
 No 423 (67.7) 10.0 (9.0-11.0)   0.000   Reference  
 Yes 202 (32.3) 7.2 (5.7-8.7)    0.395 1.485 (1.218-1.810) 0.000
Number of distant organ metastasis
 0 462 (73.9) 11.5 (10.6-12.4) 112.810 0.000   Reference  
 1 111 (17.8) 6.0 (4.9-7.1)    0.473 1.604 (1.170-2.199) 0.003
 ≥2 52 (8.3) 3.7 (2.8-4.6)    0.708 2.030 (1.347-3.062) 0.001
Adjuvant chemotherapy
 No 569 (91.0) 8.9 (8.1-9.7) 16.559 0.000   Reference  
 Yes 56 (9.0) 22.3 (14.7-29.9)    -0.701 2.015 (1.412-2.877) 0.000