Table 1 Univariate and Multivariate analysis of prognostic factors for PC
Factors | n(%) | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
mOS(95%CI) | χ2 | p | B | HR(95%CI) | P | ||
Age (years) | |||||||
 ≤40 | 17 (2.7) | 7.4 (4.1-10.7) | 13.178 | 0.010 |  | Reference |  |
 41-50 | 72 (11.5) | 12.0 (9.9-14.1) |  |  | -0.154 | 0.857 (0.461-1.594) | 0.626 |
 51-60 | 215 (34.4) | 8.7 (7.5-9.9) |  |  | 0.128 | 1.136 (0.638-2.024) | 0.664 |
 61-70 | 224 (35.8) | 10.3 (8.8-11.8) |  |  | 0.125 | 1.133 (0.637-2.016) | 0.671 |
 ≥71 | 97 (15.5) | 7.3 (5.4-9.2) |  |  | 0.273 | 1.314 (0.719-2.401) | 0.375 |
Sex | |||||||
 Male | 341 (54.6) | 8.6 (7.5-9.7) | 2.412 | 0.120 | - | - | - |
 Female | 284 (45.4) | 10.5 (9.2-11.8) |  |  | - | - | - |
Pain on the back and loin | |||||||
 No | 463 (74.1) | 9.5 (8.4-10.6) | 0.094 | 0.759 | - | - | - |
 Yes | 162 (25.9) | 9.1 (7.4-10.8) |  |  | - | - | - |
Smoking history | |||||||
 No | 396 (63.4) | 9.8 (8.8-10.8) | 1.243 | 0.265 | - | - | - |
 Yes | 229 (36.6) | 8.5 (7.1-9.9) |  |  | - | - | - |
Diabetes history | |||||||
 No | 352 (43.7) | 9.0 (8.0-10.0) | 0.446 | 0.504 | - | - | - |
 Yes | 273 (56.3) | 9.6 (8.1-11.1) |  |  | - | - | - |
CA199(U/ml) | |||||||
 <37 | 129 (20.6) | 14.5 (10.9-18.1) | 67.567 | 0.000 |  | Reference |  |
 ≥37and<200 | 159 (25.4) | 11.0 (9.1-12.9) |  |  | 0.282 | 1.326 (0.984-1.788) | 0.064 |
 ≥200and<400 | 89 (14.2) | 10.7 (8.7-12.7) |  |  | 0.399 | 1.490 (1.057-2.099) | 0.023 |
 ≥400and<800 | 101 (16.2) | 9.0 (7.9-10.1) |  |  | 0.474 | 1.606 (1.157-2.229) | 0.005 |
 ≥800 | 147 (23.5) | 5.7 (5.0-6.4) |  |  | 0.767 | 2.153 (1.558-2.975) | 0.000 |
CEA (ng/ml) | |||||||
 <5 | 400 (64.0) | 11.0 (9.9-12.1) | 22.771 | 0.000 |  | Reference |  |
 ≥5 | 225 (36.0) | 6.7 (6.0-7.4) |  |  | 0.187 | 1.205 (0.983-1.478) | 0.073 |
Albumin(g/L) | |||||||
 <35 | 76 (12.2) | 6.7 (4.5-8.9) | 5.128 | 0.024 |  | Reference |  |
 ≥35 | 549 (87.8) | 9.7 (8.8-10.6) |  |  | -0.137 | 0.872 (0.643-1.183) | 0.379 |
Total bilirubin (umol/l) | |||||||
 <22 | 342 (54.7) | 9.0 (8.0-10.0) | 8.922 | 0.030 |  | Reference |  |
 ≥22and<100 | 74 (11.8) | 7.0 (4.4-9.6) |  |  | 0.262 | 1.300 (0.950-1.799) | 0.102 |
 ≥100and<200 | 97 (15.5) | 10.7 (8.2-13.2) |  |  | -0.060 | 0.942 (0.702-1.264) | 0.689 |
 ≥200 | 112 (17.9) | 11.3 (8.9-13.7) |  |  | 0.031 | 1.032 (0.767-1.388) | 0.836 |
Peripancreatic invasion | |||||||
 No | 242 (38.7) | 13.8 (11.3-16.3) | 32.275 | 0.000 |  | Reference |  |
 Yes | 383 (61.3) | 7.4 (6.5-8.3) |  |  | 0.207 | 1.230 (0.995-1.519) | 0.055 |
Degree of weight loss (kg) | |||||||
 <5 | 358 (57.3) | 10.7 (9.6-11.8) | 7.755 | 0.000 |  | Reference |  |
 ≥5 | 267 (42.7) | 7.8 (6.8-8.8) |  |  | 0.162 | 1.176 (0.969-1.427) | 0.102 |
NLRa | |||||||
 <2 | 135 (21.6) | 8.7 (6.9-10.5) | 1.765 | 0.184 | - | - | - |
 ≥2 | 490 (87.4) | 9.6 (8.6-10.6) |  |  | - | - | - |
NLRb | |||||||
 <3 | 307 (49.1) | 9.6 (8.2-11.0) | 0.050 | 0.823 | - | - | - |
 ≥3 | 318 (50.9) | 9.1 (7.8-10.4) |  |  | - | - | - |
NLRc | |||||||
 <4 | 375 (60.0) | 9.7 (8.6-10.8) | 1.264 | 0.261 | - | - | - |
 ≥4 | 250 (40.0) | 9.0 (8.0-10.0) |  |  | - | - | - |
NLRd | |||||||
 <5 | 545 (87.2) | 10.0 (9.1-10.9) | 8.602 | 0.003 |  | Reference |  |
 ≥5 | 80 (12.8) | 7.4 (5.5-9.3) |  |  | 0.296 | 1.344 (1.021-1.769) | 0.035 |
Operative procedure | |||||||
 Without operation | 179 (28.6) | 6.0 (5.3-6.7) | 65.658 | 0.000 |  | Reference |  |
 Palliative operation | 81 (13.0) | 6.0 (5.2-6.8) |  |  | -0.050 | 0.951 (0.688-1.316) | 0.762 |
 Radical resection | 365 (58.4) | 12.3 (10.3-14.3) |  |  | -0.310 | 0.734 (0.573-0.940) | 0.014 |
Tumor location | |||||||
 Head | 413 (66.1) | 9.9 (8.7-11.2) | 4.484 | 0.106 | - | - | - |
 Body/tail | 207 (33.1) | 8.4 (6.7-10.1) |  |  | - | - | - |
 All | 5 (0.8) | 11.0 (8.9-13.1) |  |  | - | - | - |
Tumor size (cm) | |||||||
 d<2 | 36 (5.8) | 12.0 (2.3-21.7) | 9.756 | 0.000 |  | Reference |  |
 2≤d<4 | 314 (50.2) | 10.4 (9.2-11.6) |  |  | -0.229 | 0.796 (0.527-1.201) | 0.277 |
 d≥4 | 275 (44.0) | 8.2 (7.0-9.4) |  |  | -0.035 | 0.966 (0.630-1.480) | 0.873 |
Hepatic metastasis | |||||||
 No | 540 (86.4) | 10.7 (9.7-11.7) | 82.708 | 0.000 |  | Reference |  |
 Yes | 85 (13.6) | 4.5 (3.3-5.7) |  |  | 0.190 | 1.209 (0.850-1.720) | 0.290 |
Lymph node metastasis | |||||||
 No | 423 (67.7) | 10.0 (9.0-11.0) |  | 0.000 |  | Reference |  |
 Yes | 202 (32.3) | 7.2 (5.7-8.7) |  |  | 0.395 | 1.485 (1.218-1.810) | 0.000 |
Number of distant organ metastasis | |||||||
 0 | 462 (73.9) | 11.5 (10.6-12.4) | 112.810 | 0.000 |  | Reference |  |
 1 | 111 (17.8) | 6.0 (4.9-7.1) |  |  | 0.473 | 1.604 (1.170-2.199) | 0.003 |
 ≥2 | 52 (8.3) | 3.7 (2.8-4.6) |  |  | 0.708 | 2.030 (1.347-3.062) | 0.001 |
Adjuvant chemotherapy | |||||||
 No | 569 (91.0) | 8.9 (8.1-9.7) | 16.559 | 0.000 |  | Reference |  |
 Yes | 56 (9.0) | 22.3 (14.7-29.9) |  |  | -0.701 | 2.015 (1.412-2.877) | 0.000 |