From: Prognostic factors for elderly gastric cancer patients who underwent gastrectomy
Valuables | n | MST (months) | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|---|---|
HR | (95%CI) | p | HR | (95%CI) | p | |||
Age (year) | ||||||||
≥ 80, < 84 | 101 | > 120 | Reference | Reference | ||||
≥ 85, < 89 | 53 | 77.5 | 1.16 | (0.68–1.96) | 0.59 | 0.89 | (0.49–1.65) | 0.72 |
≥ 90 | 12 | 29.7 | 2.55 | (1.30–5.00) | < 0.01 | 2.09 | (0.87–5.03) | 0.10 |
Sex | ||||||||
Male | 113 | 62.3 | Reference | |||||
Female | 53 | > 109 | 1.04 | (0.63–1.71) | 0.89 | |||
ECOG-PS | ||||||||
0 | 81 | 85.9 | Reference | Reference | ||||
1 | 47 | 48.5 | 1.25 | (0.71–2.21) | 0.44 | 0.85 | (0.44–1.65) | 0.64 |
2 | 28 | 28.7 | 1.74 | (0.94–3.25) | 0.08 | 1.54 | (0.75–3.15) | 0.24 |
3 | 10 | 14.9 | 3.75 | (1.62–8.67) | < 0.01 | 1.44 | (0.47–4.38) | 0.52 |
ASA-PS | ||||||||
1,2 | 118 | 85.9 | Reference | Reference | ||||
3,4 | 47 | 20.8 | 2.60 | (1.58–4.28) | < 0.01 | 2.30 | (1.24–4.27) | < 0.01 |
PNI | ||||||||
≥ 45 | 77 | > 120 | Reference | Reference | ||||
≥ 40, < 45 | 35 | 77.5 | 1.52 | (0.80–2.91) | 0.20 | 1.82 | (0.87–3.79) | 0.11 |
< 40 | 53 | 22.7 | 2.62 | (1.54–4.45) | < 0.01 | 1.39 | (0.68–2.86) | 0.36 |
POSSUM physiological score | ||||||||
≥ 20, ≤ 29 | 99 | 79.2 | Reference | Reference | ||||
≥ 30, ≤ 39 | 56 | 54.0 | 1.13 | (0.68–1.88) | 0.63 | 0.68 | (0.38–1.20) | 0.18 |
≥ 40 | 11 | 6.7 | 3.95 | (1.89–8.24) | < 0.01 | 2.00 | (0.78–5.16) | 0.15 |
Cardiac signs and chest radiography signs | ||||||||
No failure | 34 | 70.2 | Reference | |||||
Diuretic, digoxin, antianginal or hypertensive therapy | 61 | 55.6 | 1.06 | (0.57–1.98) | 0.85 | |||
Peripheral edema, warfarin therapy, borderline cardiomegaly | 60 | 74.1 | 1.03 | (0.55–1.94) | 0.93 | |||
Raised jugular venous pressure, cardiomegaly | 11 | 36.6 | 1.64 | (0.63–4.27) | 0.31 | |||
Respiratory history | ||||||||
No dyspnea | 69 | 51.2 | Reference | |||||
Dyspnea on exertion, mild COPD | 75 | 86.7 | 0.69 | (0.42–1.13) | 0.14 | |||
Limiting dyspnea, moderate COPD | 9 | 29.7 | 2.18 | (1.00–4.76) | 0.05 | |||
Dyspnea at rest, fibrosis or consolidation | 13 | 24.3 | 2.13 | (0.93–4.88) | 0.07 | |||
Surgical approach | ||||||||
Open | 120 | 40.2 | Reference | Reference | ||||
Laparoscopic | 46 | 85.9 | 0.45 | (0.25–0.82) | < 0.01 | 1.58 | (0.64–3.89) | 0.32 |
Extent of gastrectomy | ||||||||
Distala | 105 | 85.9 | Reference | Reference | ||||
Totalb | 37 | 20.8 | 2.40 | (1.42–4.05) | < 0.01 | 2.17 | (1.10–4.31) | 0.03 |
Proximal | 11 | 29.3 | 2.31 | (1.07–4.99) | 0.03 | 4.05 | (1.45–11.3) | < 0.01 |
Local | 13 | > 97.6 | 0.79 | (0.31–2.02) | 0.62 | 0.08 | (0.01–0.90) | 0.04 |
Extent of lymphadenectomy | ||||||||
≥ D2 | 39 | > 120 | Reference | Reference | ||||
D1+ | 73 | 77.5 | 1.20 | (0.62–2.33) | 0.58 | 1.42 | (0.66–3.04) | 0.37 |
D1 | 37 | 22.4 | 2.56 | (1.30–5.04) | < 0.01 | 2.00 | (0.90–4.41) | 0.09 |
D0 | 17 | 62.3 | 1.13 | (0.45–2.84) | 0.80 | 12.4 | (1.58–97.7) | 0.02 |
Histological classification | ||||||||
tub,pap | 103 | 77.5 | Reference | |||||
pos,sig | 50 | 28.6 | 1.63 | (0.99–2.68) | 0.05 | |||
other | 13 | > 109 | 0.95 | (0.38–2.41) | 0.91 | |||
pStage | ||||||||
I | 71 | 85.9 | Reference | Reference | ||||
II | 49 | 48.5 | 2.00 | (1.09–3.67) | 0.03 | 2.39 | (1.03–5.56) | 0.04 |
III | 33 | 20.8 | 3.16 | (1.68–5.95) | < 0.01 | 3.03 | (1.24–7.40) | 0.02 |
IV | 13 | 6.1 | 9.93 | (4.45–22.2) | < 0.01 | 5.44 | (1.17–25.4) | 0.03 |
Residual tumor | ||||||||
R0 | 151 | 68.5 | Reference | Reference | ||||
R1 | 15 | 11.5 | 2.92 | (1.48–5.73) | < 0.01 | 2.11 | (0.48–9.40) | 0.33 |
Postoperative complication ≥ CD II | ||||||||
No | 121 | 68.5 | Reference | |||||
Yes | 45 | 44.8 | 1.46 | (0.88–2.44) | 0.14 | |||
Postoperative chemotherapy | ||||||||
No | 156 | 62.3 | Reference | |||||
Yes | 10 | > 83.4 | 1.37 | (0.55–3.41) | 0.50 |