Table 2 Univariate and multivariate Cox proportion hazard regression analysis for OS

Age (≥ 65 vs. < 65)

1.309 (0.679–2.522)

0.421

Gender (male vs. female)

1.298 (0.709–2.373)

0.397

Tumor location (left colon vs. rectum)

0.586 (0.279–1.233)

0.159

Tumor location (right colon vs. rectum)

1.267 (0.625–2.568)

0.511

Size (≥ 5 cm vs. < 5cm)

1.300 (0.731–2.310)

0.371

Histological type (others vs. adenocarcinoma)

0.733 (0.227–2.364)

0.604

Differentiation (poor vs.well/moderate)

1.569 (0.875–2.811)

0.130

Lymphovascular invasion (positive vs. negative)

2.006 (1.106–3.637)

0.022

0.865 (0.427–1.751)

0.687

Perineural invasion (positive vs. negative)

2.354 (0.844–6.557)

0.102

Harvested LNs

0.960 (0.917–1.003)

0.073

0.945 (0.909–0.992)

0.021

pT category (T4 vs. T1–3)

1.316 (0.732–2.364)

0.358

 N0

Ref.

Ref.

 N1

3.422 (1.750–6.690)

< 0.001

2.500 (1.179–5.302)

0.017

 N2

3.960 (1.794–8.739)

< 0.001

5.115 (2.236–11.701)

< 0.001

CEA (positive vs. negative)

1.310 (0.738–2.324)

0.355

CA199 (positive vs. negative)

0.845 (0.394–1.807)

0.664

Cholesterol (high vs. low)

0.947 (0.339–2.639)

0.917

Triglyceride (high vs. low)

0.457 (0.180–1.155)

0.098

0.495 (0.176–1.390)

0.181

NLR (high vs. low)

1.730 (0.835–3.578)

0.140

CLR (high vs. low)

2.702 (1.500–4.867)

< 0.001

2.142 (1.254–3.659)

0.005