Fig. 5

LARP1 was a target of miR-1287-5p in lung cancer. A The putative binding targets of miR-1287-5p were predicted by miRDB, TargetScanHuman, and Starbase 3.0. B The expression levels of 10 selected mRNAs were detected by RT-qPCR assay in lung tumor tissues (n = 3) and normal lung tissues (n = 3). C–F The expression level of LARP1 was assessed by RT-qPCR and western blot assays in lung cancer tissues (N = 60) and cells. G, H The relationship between LARP1 and miR-1287-5p or circ_0047921 was analyzed in lung cancer tissues. I Binding regions between LARP1 and miR-1287-5p were shown. J, K Dual-luciferase reporter assay was conducted to assess the luciferase activity in A549 and H1299 cells co-transfected with LARP1 3′UTR-WT/MUT and miR-1287-5p/miR-NC. *P < 0.05