Fig. 5

CeRNA network of activated memory CD4 T cells and CD8 T cell-related genes. The miRNAs of activated memory CD4 T cells and CD8 T cell-related genes were predicted using miRWalk 3.0, and miRNA-target interaction pairs in the TargetScan, MiRDB, and MirTarBase databases were obtained using a threshold of score > 0.95. In addition, the HMDD V3.2 database was used to further validate and screen the predicted miRNA using the keywords “Carcinoma, Hepatocellular”. The lncRNAs-miRNAs relationship between activated memory CD4 T cells and CD8 T cell-related genes was predicted using the DIANA-LncBase database. Finally, activated memory CD4 T cell- and CD8 T cell-related gene lncRNA-miRNA-mRNA network was constructed utilizing Cytoscape software. EOMES was regulated by has-miR-23b-3p and has-miR-23b-3p were regulated by lncRNA AC104820.2. EOMES was regulated by has-miR-23a-3p and has-miR-23a-3p was regulated by lncRNA AC000476.1. A ceRNA network of activated memory CD4 T cell-related genes. B ceRNA network of CD8 T cell-related genes. Red nodes represent upregulated DEGs, green triangles represent miRNA, and the red rhombi represent upregulated lncRNAs