Skip to main content

Table 3 Univariate and multivariate analysis of risk factors in relation to DFS in ICC

From: The prognostic value of arginase-1 and glypican-3 expression levels in patients after surgical intrahepatic cholangiocarcinoma resection

Parameter

N

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

Gender

 Female

112

1.155 (0.987‑1.351)

0.062

  

 Male

125

    

Age (years)

 < 60

108

0.924 (0.677‑1.261)

0.606

  

 ≥ 60

129

    

Arg-1

 Low

207

2.665 (1.740‑4.082)

< 0.001

2.258 (1.447‑3.525)

0.001

 High

30

    

GPC-3

 Low

201

1.843 (1.222‑2.778)

0.002

1.548 (1.011‑2.372)

0.045

 High

36

    

MUC-1

 Low

93

1.218 (0.881‑1.684)

0.218

  

 High

144

    

Tumor size (cm)

 < 5

142

1.362 (1.015‑1.864)

0.045

1.121 (0.808‑1.555)

0.493

 ≥ 5

95

    

Tumor number

 Single

167

1.253 (0.899‑1.746)

0.167

  

 Multiple

70

    

Lymph node metastasis

 No

134

1.890 (1.383‑2.583)

< 0.001

1.474 (0.852‑2.550)

0.165

 Yes

103

    

Vascular invasion

 No

133

1.780 (1.303‑2.432)

< 0.001

1.222 (0.798‑1.872)

0.356

 Yes

104

    

Nerve invasion

 No

206

1.212 (0.772‑1.902)

0.387

  

 Yes

31

    

Differentiation

 W+M

144

0.845 (0.617‑1.158)

0.278

  

 P

93

    

TNM

 I+II

127

1.694 (1.240‑2.314)

0.001

1.146 (0.722‑1.820)

0.564

 III+IV

110

    

AFP (ng/mL)

 < 25

165

0.874 (0.623‑1.226)

0.418

  

 ≥ 25

72

    

CEA (ng/mL)

 < 5

134

1.184 (0.867‑1.617)

0.271

  

 ≥ 5

103

    

CA19-9 (IU/L)

 < 37

141

1.171 (0.854‑1.604)

0.310

  

 ≥ 37

96

    

TBIL (μmol/L)

 < 17.1

92

0.892 (0.650‑1.224)

0.465

  

 ≥ 17.1

145

    

ALB (g/L)

 < 35

163

1.202 (0.865‑1.669)

0.256

  

 ≥ 35

74

    

ALT (U/L)

 < 40

96

1.022 (0.744‑1.402)

0.891

  

 ≥ 40

141

    

Chemotherapy

 No

139

0.888 (0.647‑1.219)

0.446

  

 Yes

98

   Â