Table 3 Univariate and multivariate analyses of clinicopathological factors affecting HCC recurrence of patients after liver resection in different eras

 Age (years)

0.868

-

0.847

-

  < 60

3.52

2.30–4.74

3.91

2.34–5.48

  ≥ 60

3.45

2.03–4.88

5.26

2.13–8.39

 Gender

0.976

-

0.539

-

  Female

3.50

0.01–9.83

3.29

1.23–5.35

  Male

3.46

2.41–4.49

4.57

3.03–6.11

 Hepatitis B virus

0.524

-

0.071

-

  Positive

3.35

2.75–3.96

2.96

1.97–3.94

  Negative

5.29

2.98–7.60

6.18

1.87–10.49

 Hepatitis C virus

0.293

-

0.444

-

  Positive

9.96

2.96–16.96

5.72

4.04–7.40

  Negative

3.35

2.82–3.89

3.55

1.92–5.18

-

 ICG 15 min (%)

0.720

-

0.984

  < 10

4.31

2.60–6.02

3.35

0.84–5.87

  ≥ 10

3.52

2.68–4.36

3.42

2.14–4.70

 AFP (ng/ml)

0.931

-

0.328

-

  ≥ 400

3.39

2.78–4.00

2.56

1.81–3.32

  < 400

4.73

2.68–6.78

6.18

4.02–8.34

 Tumor capsule

0.245

-

0.153

-

  Presence

4.37

2.72–7.87

5.20

3.83–6.56

  Absence

3.45

2.77–4.14

2.14

1.34–2.93

 Satellite nodule

0.511

-

0.663

-

  Presence

3.52

2.39–4.65

4.18

1.56–6.79

  Absence

3.45

0.65–6.25

4.57

2.18–6.96

 Extent of liver resection

0.593

-

0.825

-

  < 3 segments

2.89

1.21–4.58

4.87

0.85–8.88

  ≥ 3 segments

4.08

2.87–5.29

4.01

2.34–5.68

 Resection margin

0.012

0.062

0.304

-

  < 0.5 cm

1.38

0.43–2.33

2.01 (0.97–4.18)

2.99

0.46–5.52

  ≥ 0.5 cm

4.31

2.68–5.94

1

4.87

3.21–6.52

 Maximum tumor size

0.717

-

0.006

  < 5cm

3.45

0.01–9.61

12.82

0.01–27.85

1

  ≥ 5cm

3.52

2.39–4.65

3.35

2.49–4.22

1.92 (1.11–3.31)

0.019

 Portal vein invasion

0.044

0.036

  Vp2

3.35

2.64–4.07

1

5.82

3.93–7.71

1

  Vp3

4.73

2.19–7.28

0.95 (0.49–1.81)

0.864

3.91

2.44–5.39

0.88 (0.47–1.67)

0.705

  Vp4

2.70

0.01–5.80

2.21 (0.75–6.48)

0.150

1.61

0.01–3.21

2.98 (1.04–8.48)

0.041