Table 2 Meta-analysis of miR-140 expression and prognosis in cancers

OS

12 (1386)

0.728 (0.601-0.882)

73.8

< 0.001

3.25

0.001

Postoperative OS

9 (873)

0.734 (0.594-0.907)

77.6

< 0.001

2.86

0.004

Non-postoperative OS

3 (513)

0.636 (0.474-0.854)

0.0

0.377

3.01

0.003

Cancer type

 Digestive system cancer

5 (500)

0.675 (0.538-0.848)

51.1

0.085

3.37

0.001

 Digestive tract cancer

4 (380)

0.709 (0.565-0.889)

51.4

0.104

2.97

0.003

 Head and neck cancer

4 (635)

0.603 (0.456-0.797)

7.8

0.354

3.55

< 0.001

Analysis method

 Multivariate analysis

6 (677)

0.716 (0.518-0.990)

80.8

< 0.001

2.02

0.043

 Univariate analysis

9 (1077)

0.727 (0.652-0.809)

16.9

0.292

5.81

< 0.001

Publication date

 < 5 years

9 (1059)

0.773 (0.615-0.973)

73.5

< 0.001

2.19

0.028

 ≥ 5 years

3 (327)

0.618 (0.427-0.876)

55.9

0.104

2.71

0.007

Size

 < 100

4 (270)

0.832 (0.623-1.112)

85.8

< 0.001

1.24

0.215

 > 100

8 (1116)

0.699 (0.602-0.811)

34.4

0.153

4.73

< 0.001

Cutoff value

 Median

6 (724)

0.759 (0.671-0.858)

4.1

0.391

4.39

< 0.001

 Optimal cutoff

6 (662)

0.721 (0.525-0.989)

83.5

< 0.001

2.03

0.043

Detected sample

 Tissue

9 (915)

0.688 (0.539-0.880)

80.0

< 0.001

2.98

0.003

 Blood

3 (471)

0.781 (0.660-0.923)

0.0

0.806

2.90

0.004