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Table 2 Variables associated with OS according to the Cox PH regression model

From: A novel nomogram based on cardia invasion and chemotherapy to predict postoperative overall survival of gastric cancer patients

Variable

Univariable analysis

Multivariable analysis

HR

95% CI

P-value

HR

95% CI

P-value

Age, years

 < 70

Ref

  

Ref

  

 ≥ 70

1.526

1.419–1.642

< 0.001

1.671

1.546–1.806

< 0.001

Sex

 Male

Ref

     

 Female

0.973

0.903–1.049

0.476

   

Race

 White

Ref

  

Ref

  

 Black

1.043

0.934–1.163

0.456

1.079

0.965–1.207

0.183

 Other

0.806

0.738–0.880

< 0.001

0.857

0.783–0.939

0.001

Location

 Cardia

Ref

  

Ref

  

 Non-cardia

0.906

0.835–0.983

0.018

0.762

0.699–0.831

< 0.001

Grade

 Well

Ref

  

Ref

  

 Moderately

1.515

1.182–1.942

0.001

0.972

0.756–1.249

0.824

 Poorly

2.064

1.624–2.623

< 0.001

1.153

0.902–1.474

0.257

T stage

 T1

Ref

  

Ref

  

 T2

2.903

2.515–3.349

< 0.001

2.04

1.741–2.389

< 0.001

 T3

3.896

3.371–4.504

< 0.001

2.265

1.919–2.674

< 0.001

 T4

5.31

4.547–6.201

< 0.001

2.683

2.242–3.210

< 0.001

N stage

 N0

Ref

  

Ref

  

 N1

2.051

1.828–2.302

< 0.001

1.981

1.749–2.243

< 0.001

 N2

3.527

3.147–3.952

< 0.001

3.308

2.912–3.758

< 0.001

 N3

5.446

4.861–6.102

< 0.001

4.431

3.876–5.065

< 0.001

M stage

 M0

Ref

  

Ref

  

 M1

2.891

2.611–3.200

< 0.001

1.888

1.698–2.099

< 0.001

Tumor size, mm

 < 2

Ref

  

Ref

  

 2~10

2.477

2.122–2.892

< 0.001

1.158

0.980–1.369

0.085

 ≥ 10/diffuse

4.632

3.861–5.558

< 0.001

1.57

1.289–1.913

< 0.001

Chemotherapy

 No/unknown

Ref

  

Ref

  

 Yes

0.936

0.870–1.006

0.073

0.556

0.513–0.602

< 0.001

  1. HR hazard ratio, CI confidence interval, Ref reference