Table 4 Predictors for upgrade to ductal carcinoma in situ (DCIS) with invasive component (IC) in pre-operative biopsy diagnosed DCIS patients
N = 682 | Post-OP pure DCIS (N = 449) | Post-OP upgrade to DCIS-IC (N = 233) | P value |
|---|---|---|---|
Age, year | 52 ± 9.8 | 52.9 ± 10.8 | 0.29 |
Location | Â | Â | 0.62 |
Right | 219(48.8) | 109(46.8) | Â |
Left | 230(51.2) | 124(53.2) | Â |
Biopsy method | N/A = 2 | N/A = 1 |  < 0.01 |
CNB | 233(52.1) | 188(81) | Â |
Stereotactic biopsy | 140(31.3) | 27(11.6) | Â |
Excisional biopsy | 71(15.9) | 17(7.3) | Â |
MMG | 3(0.7) | 0(0) | Â |
Sonogram tumor size, cm | 1.9 ± 1.1 | 2.2 ± 1.2 |  < 0.01 |
Mammogram tumor size, cm | 2.4 ± 1.3 | 2.8 ± 1.1 | 0.14 |
MRI tumor size, cm | 3.6 ± 2.2 | 4.5 ± 2.1 |  < 0.01 |
Pathology tumor sizea, cm | 2.7 ± 2.7 | 1.4 ± 1.9 |  < 0.01 |
Gross tumor sizeb, cm | 3.3 ± 2.4 | 3.8 ± 2.4 | 0.02 |
Stage (N/A = 33) | N/A = 31 | N/A = 2 |  < 0.01 |
0 | 381(91.1) | 9(3.9) | Â |
I | 26(6.2) | 157(68.0) | Â |
II | 10(2.4) | 55(23.8) | Â |
III | 1(0.2) | 10(4.3) | Â |
Grade (N/A = 74) | N/A = 44 | N/A = 30 |  < 0.01 |
I | 28(6.9) | 48(23.6) | Â |
II | 211(52.1) | 126(62.1) | Â |
III | 166(41.0) | 29(14.3) | Â |
ER | N/A = 24 |  |  < 0.01 |
Positive | 335(78.8) | 149(63.9) | Â |
Negative | 90(21.2) | 84(36.1) | Â |
PR (N/A = 33) | N/A = 33 |  |  < 0.01 |
Positive | 303(72.8) | 135(57.9) | Â |
Negative | 113(27.2) | 98(42.1) | Â |
HER-2 (N/A = 203) | N/A = 199 | N/A = 4 | 0.25 |
Positive | 99(39.6) | 79(34.5) | Â |
Negative | 151(60.4) | 150(65.5) | Â |
MRI LN metastasis | N/A = 184 | N/A = 91 | 0.01 |
Yes | 50(18.9) | 44(31.0) | Â |
No | 215(81.1) | 98(69.0) | Â |
Lymph node stage | N/A = 61 | N/A = 22 |  < 0.01 |
N0 | 385(99.2) | 164(77.7) | Â |
N1 | 2(0.5) | 38(18.0) | Â |
N2 | 0(0) | 7(3.3) | Â |
N3 | 1(0.3) | 2(0.9) | Â |
OP method |  |  |  < 0.01 |
Total | 255(56.8) | 175(75.1) | Â |
Partial | 194(43.2) | 58(24.9) | Â |
LN meta | N/A = 30 | N/A = 3 |  < 0.01 |
Yes | 3(0.7) | 46(20.0) | Â |
No | 416(99.3) | 184(80.0) | Â |
Method_LN |  |  |  < 0.01 |
SLNB | 365(81.3) | 163(70.0) | Â |
SLNB + ALND | 14(3.1) | 35(15.0) |  |
ALND | 18(4.0) | 25(10.7) | Â |
ND | 52(11.6) | 10(4.3) | Â |