Predicting factors of central lymph node metastasis and BRAFV600E mutation in Chinese population with papillary thyroid carcinoma

Table 4 Relationships between the BRAF^V600E mutation and clinicopathologic characteristics of 943 patients with PTC

Variable	The overall PTC					PTC > 10 mm group					PTMC
	Positive	Negative	Uni- and multivariate analysis			Positive	Negative	Uni- and multivariate analysis			Positive	Negative	Uni- and multivariate analysis
	n(%)	n(%)	P	P	OR(95CI)	n(%)	n(%)	P	P	OR(95CI)	n(%)	n(%)	P	P	OR(95CI)
Gender
Male	199(85)	34(15)	0.974			86(80)	21(20)	0.324			113(90)	13(10)	0.287
Female	607(86)	103(14)	0.974			225(85)	41(15)	0.324			382(86)	62(14)	0.287
Age (years) ^*	46.3 ± 11.8	44.0 ± 11.9	0.03	< 0.001	1.04 (1.02–1.06)	46.3 ± 11.7	41.0 ± 3.1	0.002	0.004	1.04 (1.01–1.06)	46.2 ± 10.9	46.6 ± 10.1	0.804
Tumor diameter (mm) ^*	1.1 ± 0.9	1.3 ± 1.2	0.04	0.283		1.9 ± 0.9	2.3 ± 1.2	0.04	0.756		0.6 ± 0.2	0.5 ± 0.2	< 0.001	< 0.001	8.19 (2.73–24.57)
Focality
Uni	579(84)	109(16)	0.06			209(81)	50(19)	0.039	0.057		370(86)	59(14)	0.464
Multi	227(89)	28(11)	0.06			102(90)	12(11)	0.039	0.057		125(89)	16(11)	0.464
HT
No	771(86)	122(14)	0.002	0.005	0.35 (0.17–0.73)	301(84)	57(16)	0.087			470(88)	65(12)	0.007	0.03	0.42 (0.19–0.92)
Yes	35(70)	15(30)	0.002	0.005	0.35 (0.17–0.73)	10(67)	5(33)	0.087			25(71)	10(29)	0.007	0.03	0.42 (0.19–0.92)
CLNM
No	379(86)	61(14)	0.588			87(89)	11(10)	0.095			292(85)	50(15)	0.206
Yes	427(85)	76(15)	0.588			224(81)	51(19)	0.095			203(89)	25(11)	0.206
T stage
T1	724(86)	114(14)	0.02	0.683		229(85)	39(15)	0.088			495(87)	75(13)	–
T2 + T3	82(78)	23(22)	0.02	0.683		82(78)	23(22)	0.088			–	–	–
Tumor stage
I	728(85)	128(15)	0.248			262(82)	58(18)	0.065			466(87)	70(13)	0.783
II	78(90)	9(10)	0.248			49(93)	4(8)	0.065			29(85)	5(15)	0.783

Abbreviations: PTC papillary thyroid carcinoma, PTMC papillary thyroid microcarcinoma, HT Hashimoto’s thyroiditis, CLNM central lymph node metastasis
*Numbers are presented as means ± standard deviation

ISSN: 1477-7819