Correlation between hypoxia-inducible factor-1α C1772T/G1790A polymorphisms and head and neck cancer risk: a meta-analysis

Table 1 Detailed information of the included articles

First author	Year	Country	Ethnicity	Genotyping method	SC	Case–control	Cases			Controls			Cancer type	HWE
C1772T							CC	CT	TT	CC	CT	TT
Prasad J	2018	India	Asian	Sequencing	HB	50/50	43	7	0	42	8	0	OSCC	0.539
Alves LR	2012	Brazil	Brazilian	PCR-RFLP	PB	40/88	0	1	39	0	85	3	OSCC	< 0.001
Mera-Menendez F	2012	Spain	Caucasian	PCR-RFLP	HB	118/148	85	18	15	113	27	8	Glottic laryngeal cancer	0.001
Shieh TM	2010	China	Asian	Sequencing	HB	305/96	282	23	0	89	7	0	OSCC	0.711
Chen MK	2009	China	Asian	PCR-RFLP	PB	174/347	163	10	1	334	13	0	OC	0.722
Munoz-Guerra MF	2009	Spain	Caucasian	PCR-RFLP	PB	70/148	57	6	7	113	27	8	OSCC	0.001
Tanimoto K	2003	Japan	Asian	Sequencing	PB	55/110	45	10	0	98	12	0	HNSCC	0.545
G1790A							AA	AG	GG	AA	AG	GG
Alves LR	2012	Brazil	Brazilian	PCR-RFLP	PB	40/88	37	1	2	0	7	81	OSCC	0.698
Mera-Menendez F	2012	Spain	Caucasian	PCR-RFLP	HB	111/139	0	4	107	0	9	130	Glottic laryngeal cancer	0.693
Shieh TM	2010	China	Asian	Sequencing	HB	305/96	0	24	281	0	7	89	OSCC	0.711
Chen MK	2009	China	Asian	PCR-RFLP	PB	174/347	1	20	153	0	14	333	OC	0.701
Munoz-Guerra MF	2009	Spain	Caucasian	PCR-RFLP	PB	64/139	3	21	40	0	9	130	OSCC	0.693
Tanimoto K	2003	Japan	Asian	Sequencing	PB	55/110	0	4	51	0	9	101	HNSCC	0.655

SC, source of control; OC, oral cancer; NC, nasopharyngeal carcinoma; HNC, head and neck cancer; HB, hospital-based study; PB, population-based study; HWE, Hardy-Weinberg equilibrium; PCR-RFLP, polymerase chain reaction–restriction fragment length polymorphism; PCR, polymerase chain reaction

ISSN: 1477-7819