Fig. 1

MiR-186-3p inhibits the development of cervical cancer cells. A qRT-PCR detection of the relative expression of miR-186-3p in non-tumor tissues and tumor tissues. P < 0.001 using Student’s t test. B qRT-PCR detection of the relative expression of miR-186 in HcerEpic, HeLa, CaSKi, SiHa, and C33A cells. ^** P < 0.001 compared with HcerEpic cells using ANOVA. C qRT-PCR detection of the relative expression of miR-186-3p in HeLa and SiHa cells transfected with miR-186-3p mimic and inhibitor and NC. D MTT assay detection of the viability of HeLa and SiHa cells transfected with miR-186-3p mimic and inhibitor and NC. E BrdU assay determination of the proliferation of HeLa and SiHa cells transfected with miR-186-3p mimic and inhibitor and NC. F Transwell assay measurement of the migration ability of HeLa and SiHa cells transfected with miR-186-3p mimic and inhibitor and NC. G Caspase-3 activity assay detection of cell apoptosis of HeLa and SiHa cells transfected with miR-186-3p mimic and inhibitor and NC. H Western blotting detection of the expression of cleaved caspase-3 and total caspase-3 in HeLa and SiHa cells transfected with miR-186-3p mimic and inhibitor and NC. C–H ^**, P < 0.001 compared with blank control (CON) group using ANOVA. Other abbreviations: NC, negative control; miR-mimic, miR-186-3p mimic; miR-inhibitor, miR-186-3p inhibitor