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Table 4 Histopathological outcomes in the mistletoe and non-mistletoe groups

From: Effect of mistletoe extract on tumor response in neoadjuvant chemoradiotherapy for rectal cancer: a cohort study

Variables MG (n = 15) NMG (n = 37) P-value
Tumor size (cm) 2.5 (0–4.5) 3 (0–7.7) 0.293
Histologic grade    0.151
 Well-differentiated 0 1 (2.7)  
 Moderately differentiated 6 (40.0) 25 (67.6)  
 Poorly differentiated 1 (6.7) 2 (5.4)  
 Others 8 (53.3) 9 (24.3)  
ypT after NCRT    0.005¶,**
 ypT0 8 (53.3) 8 (21.6)  
 ypT1 0 1 (2.7)  
 ypT2 5 (33.3) 4 (10.8)  
 ypT3 2 (13.3) 22 (59.5)  
 ypT4 0 2 (5.4)  
ypN after NCRT    0.161
 ypN0 13 (86.7) 21 (56.8)  
 ypN1 2 (13.3) 12 (32.4)  
 ypN2 0 4 (10.8)  
Distal resection margin (cm) 1.5 (0.2–6.0) 2.0 (0.1–5.0) 0.121
Circumferential resection margin involvement    0.498
 Yes 1 (6.7) 1 (2.7)  
 No 14 (93.3) 36 (97.3)  
Harvested lymph nodes 13 (1–18) 13 (1–35) 0.255
Lymphovascular invasion    0.04¶,**
 Yes 2 (13.3) 16 (43.2)  
 No 13 (86.7) 21 (56.8)  
Perineural invasion    0.3
 Yes 2 (13.3) 12 (32.4)  
 No 13 (86.7) 25 (67.6)  
  1. Data are presented as median (range) for continuous variables and n (%) for categorical variables
  2. Mann–Whitney test; chi-square test or Fisher’s exact test; **statistical significance (P < 0.05)
  3. MG, mistletoe group; NMG, non-mistletoe group; NCRT, neoadjuvant chemoradiotherapy