Skip to main content

Table 4 Histopathological outcomes in the mistletoe and non-mistletoe groups

From: Effect of mistletoe extract on tumor response in neoadjuvant chemoradiotherapy for rectal cancer: a cohort study

Variables

MG (n = 15)

NMG (n = 37)

P-value

Tumor size (cm)

2.5 (0–4.5)

3 (0–7.7)

0.293†

Histologic grade

  

0.151¶

 Well-differentiated

0

1 (2.7)

 

 Moderately differentiated

6 (40.0)

25 (67.6)

 

 Poorly differentiated

1 (6.7)

2 (5.4)

 

 Others

8 (53.3)

9 (24.3)

 

ypT after NCRT

  

0.005¶,**

 ypT0

8 (53.3)

8 (21.6)

 

 ypT1

0

1 (2.7)

 

 ypT2

5 (33.3)

4 (10.8)

 

 ypT3

2 (13.3)

22 (59.5)

 

 ypT4

0

2 (5.4)

 

ypN after NCRT

  

0.161¶

 ypN0

13 (86.7)

21 (56.8)

 

 ypN1

2 (13.3)

12 (32.4)

 

 ypN2

0

4 (10.8)

 

Distal resection margin (cm)

1.5 (0.2–6.0)

2.0 (0.1–5.0)

0.121†

Circumferential resection margin involvement

  

0.498¶

 Yes

1 (6.7)

1 (2.7)

 

 No

14 (93.3)

36 (97.3)

 

Harvested lymph nodes

13 (1–18)

13 (1–35)

0.255†

Lymphovascular invasion

  

0.04¶,**

 Yes

2 (13.3)

16 (43.2)

 

 No

13 (86.7)

21 (56.8)

 

Perineural invasion

  

0.3¶

 Yes

2 (13.3)

12 (32.4)

 

 No

13 (86.7)

25 (67.6)

 
  1. Data are presented as median (range) for continuous variables and n (%) for categorical variables
  2. †Mann–Whitney test; ¶chi-square test or Fisher’s exact test; **statistical significance (P < 0.05)
  3. MG, mistletoe group; NMG, non-mistletoe group; NCRT, neoadjuvant chemoradiotherapy