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Table 2 Short-term clinical outcomes of chemoradiation and surgery in the mistletoe and non-mistletoe groups

From: Effect of mistletoe extract on tumor response in neoadjuvant chemoradiotherapy for rectal cancer: a cohort study

Variables MG (n = 15) NMG (n = 37) P-value
Dose of radiation (Gy) 50.4 50.4 n/a
Concurrent chemotherapy    1.000
 Capecitabine 15 (100) 36 (97.3)  
 5-Fluorouracil 0 1 (2.7)  
cT after NCRT    0.848
 cT0 1 (6.7) 1 (2.7)  
 cT2 6 (40.0) 12 (32.4)  
 cT3 7 (46.7) 21 (56.8)  
 cT4 1 (6.7) 3 (8.1)  
cN after NCRT    0.666
 cN0 7 (46.7) 14 (37.8)  
 cN1 6 (40.0) 14 (37.8)  
 cN2 2 (13.3) 9 (24.3)  
Interval to surgery (weeks) 8.6 (6.1–12.9) 8.7 (5.9–14.1) 0.808
Type of surgery    0.506
 Low anterior resection 3 (20.0) 8 (21.6)  
 Ultra-low anterior resection 10 (66.7) 24 (64.9)  
 Abdominoperineal resection 1 (6.7) 1 (2.7)  
 Hartmann’s operation 0 3 (8.1)  
 Transanal excision 1 (6.7) 1 (2.7)  
Total operative time (h) 3.0 (0.8–4.1) 3.0 (0.2–5.7) 0.428
Estimated blood loss (mL) 20.0 (3.0–150.0) 30.0 (0–250.0) 0.385
Intraoperative transfusion    n/a
 Yes 0 0  
 No 15 (100) 37 (100)  
Length of hospital stay (days) 8 (4–37) 8 (5–51) 0.676
  1. Data are presented as median (range) for continuous variables and n (%) for categorical variables
  2. Mann–Whitney test; chi-square test or Fisher’s exact test
  3. MG, mistletoe group; NMG, non-mistletoe group; NCRT, neoadjuvant chemoradiotherapy