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Fig. 3 | World Journal of Surgical Oncology

Fig. 3

From: CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205

Fig. 3

CircASXL1 was associated with miR-1205 in CRC cells. A CircBank online database was employed to predict the binding sites between circASXL1 and miR-1205. B, D The high overexpression efficiency of miR-1205 mimic and oe-circASXL1 was determined. C The interaction between circASXL1 and miR-1205 was identified by dual-luciferase reporter assay. E, F MiR-1205 was weakly expressed in CRC tissues as well as SW480 and SW620 cells. G CircASXL1 overexpression decreased miR-1205 expression, and circASXL1 knockdown increased miR-1205 expression. Significant differences in (BD) were compared with two-tailed Student’s t tests, in (E) with Wilcoxon rank-sum test and in (F and G) with ANOVA. *P < 0.05

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