Fig. 4

Circ_0001982 directly interacted with miR-1287-5p in BC cells. a StarBasev3.0 was utilized to predict the putative binding sites between circ_0001982 and miR-1287-5p. b, c The luciferase activity was measured in MDA-MB-231 and MDA-MB-468 cells co-transfected with circ_0001982-WT or circ_0001982-MUT and miR-138-5p or miR-NC. d, e The expression of miR-138-5p was measured by qRT-PCR in breast cancer tissues and cells. f, g The level of miR-1287-5p was determined using the qRT-PCR analysis in MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment. h, i The level of miR-1287-5p was determined using the qRT-PCR analysis in MDA-MB-231 and MDA-MB-468 transfected with si-NC or si-circ_0001982. *P < 0.05