Fig. 2

Circ_0001982 knockdown inhibited glycolysis in breast cancer cells under hypoxic conditions. MDA-MB-231 and MDA-MB-468 cells in hypoxic conditions were transfected with si-NC or si-circ_0001982. a, b QRT-PCR was used to detect the transfection efficiency of si-circ_0001982. The expression of circ_0001982 in BC cells (MDA-MB-231 and MDA-MB-468) under hypoxia conditions was detected. c, d The glucose consumption in MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment was assessed. e, f Lactic acid production in MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment was evaluated. g, h Western blot was used to detect the expression of HK2 in MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment. *P < 0.05