Table 2 Subgroup analysis of overall survival
Subgroups | No. of studies | Pooled HR (95% CI) | Heterogeneity | |
|---|---|---|---|---|
I2 (%) | p value | |||
Region | ||||
Eastern | 11 | 2.164 (1.838–2.549) | 13.78 | 0.313 |
Western | 3 | 1.867 (1.560–2.33) | 0 | 0.927 |
Sample sizes | ||||
< 200 | 7 | 2.473 (1.964–3.115) | 8.535 | 0.363 |
≥ 200 | 7 | 1.885 (1.649–2.154) | 0 | 0.878 |
Stage | ||||
I–III | 6 | 1.926 (1.627–2.281) | 19.71 | 0.285 |
Include IV | 8 | 2.273 (1.872–2.761) | 0 | 0.682 |
Treatment | ||||
Surgery | 8 | 1.952 (1.680–2.268) | 13.5 | 0.325 |
Chemotherapy | 3 | 2.223 (1.539–3.210) | 8.89 | 0.333 |
Liver resection | 3 | 2.412 (1.778–3.273) | 0 | 0.658 |
Cut-off value | ||||
≥ 0.1 | 8 | 1.924 (1.682–2.200) | 0 | 0.842 |
< 0.1 | 6 | 2.382 (1.812–3.129) | 34.427 | 0.178 |
Analysis method | ||||
MV | 11 | 2.122 (1.798–2.503) | 22.476 | 0.229 |
UV | 3 | 1.960 (1.564–2.455) | 0 | 0.958 |