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Table 2 Subgroup analysis of overall survival

From: Prognostic value of the C-reactive protein to albumin ratio in colorectal cancer: an updated systematic review and meta-analysis

Subgroups No. of studies Pooled HR (95% CI) Heterogeneity
I2 (%) p value
Region
 Eastern 11 2.164 (1.838–2.549) 13.78 0.313
 Western 3 1.867 (1.560–2.33) 0 0.927
Sample sizes
 < 200 7 2.473 (1.964–3.115) 8.535 0.363
 ≥ 200 7 1.885 (1.649–2.154) 0 0.878
Stage
 I–III 6 1.926 (1.627–2.281) 19.71 0.285
 Include IV 8 2.273 (1.872–2.761) 0 0.682
Treatment
 Surgery 8 1.952 (1.680–2.268) 13.5 0.325
 Chemotherapy 3 2.223 (1.539–3.210) 8.89 0.333
 Liver resection 3 2.412 (1.778–3.273) 0 0.658
Cut-off value
 ≥ 0.1 8 1.924 (1.682–2.200) 0 0.842
 < 0.1 6 2.382 (1.812–3.129) 34.427 0.178
Analysis method
 MV 11 2.122 (1.798–2.503) 22.476 0.229
 UV 3 1.960 (1.564–2.455) 0 0.958
  1. CI confidence interval, HR hazard ratio, MV multivariate, UV univariate