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Table 2 Outcomes of included studies

From: Meta-analysis of neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for locally advanced rectal cancer

Outcomes Terms HR (95%CI) Heterogenicity Heterogenicity Effect size Effect size2
P I2 (%) Z P
pCR 6 0.62 (0.27, 1.41) 0.01 66 1.15 0.25
R0 Resection 3 1.24 (0.78, 1.98) 0.93 0 0.91 0.36
sphincter preservation 5 1.87 (1.24, 2.81) 0.20 35 3.01 0.003
Response 4 0.46 (0.27, 0.76) 0.02 68 3.02 0.003
N downstaging rates 3 1.20 (0.25, 5.79) <0.001 90 0.23 0.82
T downstaging rates 3 0.67 (0.52, 0.87) 0.36 2 2.99 0.003
Local relapse rate 3 1.12 (0.58, 2.14) 0.86 0 0.33 0.74
Distant metastases rate 2 0.84 (0.31, 2.27) 0.23 31 0.35 0.73
  1. Note: pCR pathologic complete response, HR (95%CI), hazard rate (95% confidence interval)